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This paper explores the possibilities of architectural design to benefit human condition, which encompasses physical well-being, environmental quality of life in big cities during the Climate Change era. The urban pollution is rising on a global scale. The present paper is focused on a new possibility to resolve the problem of air purification in highly-urbanized areas. The first part of the paper depicts possible usage of Titanium dioxide (TiO2) technology - nanoparticles of TiO2, as a building materials componen...