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Tons of pharmacologically active substances are used by human annually in medicine, agriculture, and for farm-animal production. The influence of pharmaceutical antibiotics (benzylpenicillin, pharmazin, and nystatin) in different doses (100, 300, 450, and 600 mg/kg) on a number of microorganisms of the chernozem region has been studied. All tested doses of pharmaceutical antibiotics had a significant inhibitory effect on the abundance of soil microorganisms. Bactericidal drugs (benzylpenicillin) are most effective...

In recent years, the input of antibiotics into soils has sharply increased. The environmental behavior of antibiotics is not well known and the precise environmental risk assessment is not practical. Long-term studies have shown the efficiency of the diagnostics and monitoring of soils with biochemical methods, particularly with the help of the indices of soil enzymatic activity. We studied the impact antibiotics (benzylpenicillin, tilosin and nystatin) at different concentrations (100, 500 mg/kg) on hydrolase (ph...