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Amiodarone (AMD) is an antiarrhythmic agent used for the treatment of ventricular arrhythmias, arterial fibrillation, and severe rhythm disorders. The main therapeutic disadvantage of AMD is its low oral bioavailability and low water solubility. The aim of the study was to obtain the hydroxylpropyl-?-cyclodextrin/AMD inclusion complex and to assess its degree of drug loading using a new HPLC method. The solubilizing effect of cyclodextrin on AMD was evaluated by the phase solubility method. The concentration of AM...

The current stage in the development of the construction industry is associated with improving the consumer properties of composite materials, increasing their operational efficiency, increasing production volumes and service lives. One of the ways to solve the problem associated with increasing the durability and reliability of materials from plant raw materials is to create compositions based on the synthesis of ceramic materials with an ordered structure by mineralization of the wood matrix with sol-gel surface...