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Amiodarone (AMD) is an antiarrhythmic agent used for the treatment of ventricular arrhythmias, arterial fibrillation, and severe rhythm disorders. The main therapeutic disadvantage of AMD is its low oral bioavailability and low water solubility. The aim of the study was to obtain the hydroxylpropyl-?-cyclodextrin/AMD inclusion complex and to assess its degree of drug loading using a new HPLC method. The solubilizing effect of cyclodextrin on AMD was evaluated by the phase solubility method. The concentration of AM...