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The long-term activity of a polymetallic ore mine in the region of Tarnita-Suceava, Romania, has resulted in an enormous amount of waste material, collected in tailing dumps and ponds. The impact of the waste materials on the surrounding ecosystem and human health are far to be fully estimated. The deposited waste has exerted negative impact on the environment, especially on the soils that host dumps and drainage waters. Heavy metals, including arsenic also interfere with the metabolism of plants, and reduce the n...

Alzheimer?s disease, the most common age-related dementia worldwide, is characterized by two pathologies: deposition of ?-amyloid plaque and neurofibrillary tangles of hyperphosphorylated tau. To this date, several factors, such as oxidative stress, metal ions, or genetic factors are associated with Alzheimer`s diseases, but there are still some question marks regarding: (i) how the misfolding and aggregation of A? occurs and which is the aggregation mechanism; (ii) how the metal ions binds to A? and how they init...