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EXPERIMENTAL MODEL OF SARS COV-2 IN YOUNG SYRIAN HAMSTERS FOR PRECLINICAL STUDIES
(STEF92 Technology, 2022-11-15, Gleb Fomin, Kairat Tabynov, Nurkeldy Turebekov, Dinara Turegeldiyeva, Rinat Islamov)
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SARS-CoV-2 researchers faced the problem of specificity for ACE-2 receptors. In mice and rats, ACE-2 has a low affinity for this virus. In contrast, the Syrian hamster (Mesocricetus auratus) when infected with SARS-CoV-2 show clinical signs of infection with this virus. Therefore, it is necessary to assess the severity of pathological lesions and immune response for relevance to preclinical new drugs against SARS-CoV-2. In this study, we studied blood counts, serum levels of Il-6, TNF-?, IFN-? and IFN-? and the hi...
Advances in Biotechnology2022