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In 2011, we developed our application for B-imaging based on binary thresholding algorithm in a selectable Region of Interest. This application has been used in many studies focused on ultrasound B-imaging in neurology; primarily for substantia nigra echogenicity examination and also for some different brain structures, e.g. mediotemporal lobe atrophy investigation. One of principal output value is an echogenicity index which is used as a marker of the echogenicity grade. Many published studies showed that is well...