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Alzheimer`s diseases (AD) is the most common age-related dementia, being characterized by accumulation of extracellular amyloid plaques in AD brains. The principal constituent of these plaques are fibrils which are primarily composed of amyloid-? peptides (A?), with 39-42 amino acid residues in length, which are the proteolysis products derived from the amyloid precursor peptide (APP). Several factors, such as oxidative stress, inflammation, metal ions or genetic factors are associated with AD. Even if metal ions ...