Peer-reviewed articles 17,970 +


Title: BENZIMIDAZOLE – PYRIDINE: A NEW TYPE OF HGHLY SENSITIVE CHEMOSENSOR FOR ZN2+
BENZIMIDAZOLE – PYRIDINE: A NEW TYPE OF HGHLY SENSITIVE CHEMOSENSOR FOR ZN2+

PlumX Article Metrics by Elsevier
Violeta Mangalagiu; Dorina Amariucai-Mantu; Dumitrela Diaconu; Vasilichia Antoci
10.5593/sgem2024v/6.2/s23.01
10.5593/sgem2024v/6.2
1314-2704
978-619-7603-78-1
English
24
6.2
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Micro and Nano Technologies for Sustainable Development
Discovery of new chemosensors for M2+ cations represent a continuously and challenging issue for researcher because of their potential applications in nano and micro technologies. Among the other metals, zinc is the second most abundant transition metal ion in human body and plays a crucial role in many biological and environmental processes. In this work we present the design, synthesis and characterization of a Zn2+ chemosensors and its coordination complexes based on podants with benzimidazole - pyridine skeleton. The new chemosensor have in the same molecule a ?–reach heterocycles (benzimidazole) and a p–deficient heterocycles (pyridine) connected via a methylene linker. The complexation ability of our podant with Zn2+ was investigated. The chemosensor proved to be highly sensitive for Zn2+ in the nanomolar range.
[1] Wang, X., Ding, Q., Groleau, R.R., Wu, L., Mao, Y., Che, F., Kotova, O., Scanlan, E.M., Lewis,S., Li,P., Tang,B., James,T., Gunnlaugsson, T. Fluorescent Probes for Disease Diagnosis. Chem. Rev., 124, 7106?7164, 2024.
[2] Tohora, N., Ahamed, S., Mahato, M., Chourasia, J., Ali, A., Das, S.K. A ratiometric, turn-on fluorosensor for specific detection of Zn2+ ions. J. Photochem. Photobiol. A, 457, 115921, 2024.
[3] Liu, H., Ding, S., Lu, Q., Jian, Y., Wei, G., Yuan, Z. A versatile Schiff Base Chemosensor for the Determination of Trace Co2+, Ni2+, Cu2+, and Zn2+ in the Water and Its Bioimaging Applications. ACS Omega, 7, 7585–7594, 2022.
[4] Wang, F., Wang, K., Kong, Q., Wang, J., Xi, D., Gu, B., Lu, S., Wei, T., Chen, X. Recent studies focusing on the development of fluorescence probes for zinc ion. Coord. Chem. Rev., 429, 213636, 2021.
[5] Luangphai, S., Thuptimdang, P., Buddhiranon, S., Chanawanno, K. Aza-BODIPY-based logic gate chemosensors and their applications. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 322, 124806, 2024.
[6] Orhan, E., Ergun, E., Sarkaya, K., Ergun, U. A novel benzimidazole-based chemosensor for fluorometric determination of zinc ions. J. Fluoresc., 31, 1833–1842, 2021.
[7] Aysha, T.S., Mohamed, M.B.I., El-Sedik, M.S., Youssef, Y.A. Multi-functional colorimetric chemosensor for naked eye recognition of Cu2+, Zn2+ and Co2+ using new hybrid azopyrazole/pyrrolinone ester hydrazone dye. Dyes Pigm., 196, 109795, 2021.
[8] Kim, A., Lee, H., Yun, D., Jung, U., Kim, K.T., Kim, C. Developing a new chemosensor targeting zinc ion based on two types of quinoline platform. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 241, 118652, 2020.
[9] Shi, Z., Han, X., Hu, W., Bai, H., Peng, B., Ji, L., Fan, Q., Li, L., Huang, W. Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations. Chem. Soc. Rev., 49, 7533-7567, 2020.
[10] Ding, Y., Zhu, W.H., Xie, Y. Development of ion chemosensors based on porphyrin analogues. Chem. Rev., 117, 2203-2256, 2017.
[11] Kaur, P., Singh, K. Recent advances in the application of BODIPY in bioimaging and chemosensing. J. Mater. Chem. C, 7, 11361-11405, 2019.
[12] Anbu, J., Paul, A., Surendranath, K., Solaiman, N.S., Pombeiro, A.J.A. benzimidazole-based new fluorogenic differential/sequential chemosensor for Cu2+, Zn2+, CN?, P2O7 4-, DNA, its live-cell imaging and pyrosequencing applications. Sens. Actuators B Chem., 337, 129785, 2021.
[13] Jung, J. M., Leea, S.Y., Namb, E., Limb, M.H., Kim, C. A highly selective turn-on chemosensor for Zn2+ in aqueous media and living cells. Sens. Actuators B Chem., 244, 1045-1053, 2017.
[14] Kim, A., Lee, H., Yun, D., Jung, U., Kim, K.T., Kim, C. Developing a new chemosensor targeting zinc ion based on two types of quinoline platform. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 241, 118652, 2020.
[15] Olaru, A., Vasilache, V., Danac, R., Mangalagiu, I.I. Antimycobacterial activity of nitrogen heterocycles derivatives: 7-(pyridine-4-yl)- indolizine derivatives. Part VII. J. Enzyme Inhib. Med. Chem., 32(1), 1291-1298, 2017.
[16] Luca, M.C., Tura, V., Mangalagiu, I.I. Considerations concerning design and mechanism of action of a new class of dual DNA intercalators. Med. Hyp., 75, 627-629, 2010.
[17] Zbancioc, Ghe., Bejan, V., Risca, M., Moldoveanu, C., Mangalagiu, I.I. Microwave assisted reactions of new azaheterocyles compounds. Molecules, 14, 403-411, 2009.
[18] Diaconu, D., Antoci, V., Mangalagiu, V., Amariucai-Mantu, D., Mangalagiu, I.I. Quinoline - imidazole/benzimidazole derivatives as dual- / multi- targeting hybrids inhibitors with anticancer and antimicrobial activity. Sci. Rep., 12, 16988, 2022.
[19] Antoci, V., Cucu, D., Zbancioc, Ghe., Moldoveanu, C., Mangalagiu, V., Amariucai-Mantu, D., Aricu, A., Mangalagiu, I.I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. Part XII. Future Med. Chem., 12(3), 207-222, 2020.
[20] Amariucai-Mantu, D., Mangalagiu, V., Ciobanu, C.I., Antoci, V. Hybrid pyridine bis-anthracene-imidazolium salt: NMR studies on Zn-acetate complexation. Molbank, M1280, 2021.
Violeta Mangalagiu is thankful for financial support to UEFISCDI, Romania, project number PN-IV-P2-2.2-MC-2024-0855.
conference
https://doi.org/10.5593/sgem2024v/6.2/s23.01
Download PDF
Proceedings of 24th International Multidisciplinary Scientific GeoConference SGEM 2024
24th International Multidisciplinary Scientific GeoConference SGEM 2024, 27 - 30 November, 2024
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Russian Acad Arts; Turkish Acad Sci.
3-8
27 - 30 November, 2024
website
10153
chemosenzor, Zn2+, pyridine, benzimidazole

25th SGEM International Conference on Earth & Planetary Sciences


International GeoConference SGEM2025
27 June - 6 July, 2025 / Albena, Bulgaria

Read More		   

SGEM Vienna GREEN "Green Science for Green Life"


Extended Scientific Sessions SGEM Vienna GREEN
3 -6 December, 2025 / Vienna, Austria

Read More
   

A scientific platform for Art-Inspired Scientists!


The Magical World Where Science meets Art
Vienna, Austria

Read More