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Title: BIOFUNCTIONALIZED IRON OXIDE (II, III) NANOPARTICLES AS DIAGNOSTIC TOOLS FOR AUTOIMMUNE DISEASES
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BIOFUNCTIONALIZED IRON OXIDE (II, III) NANOPARTICLES AS DIAGNOSTIC TOOLS FOR AUTOIMMUNE DISEASES
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1314-2704
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English
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18
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6.1
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Autoimmune diseases affect approximately 5% of the population worldwide. Generally,
these disorders induce high degree of morbidity and disability and therefore, they have a significant social and economic impact. The precise diagnosis of specific autoimmune response is necessary for adequate treatment of the patient. Accordingly, the diagnostic assays for autoimmune diseases are continuously developing and improving. Biofunctionalized nanoparticles represent a promising novel approach in this field. Our group has developed a mechanism for efficient biofunctionalization of iron oxide (II, III) nanoparticles (ION) with molecules used for detection of biomarkers specific for rheumatoid arthritis. Purified biofunctionalized ION were tested with serum samples from healthy individuals, patients with rheumatoid arthritis and patients with another autoimmune disorder. We were able to detect rheumatoid arthritis-specific biomarkers using biofunctionalized ION. The efficiency of the nanoparticle-based assay was similar to the conventional enzyme-linked immunosorbent assay. Our results provide a basis for development of new utility models for rapid and sensitive diagnostic assays for autoimmune diseases. |
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conference
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18th International Multidisciplinary Scientific GeoConference SGEM 2018
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18th International Multidisciplinary Scientific GeoConference SGEM 2018, 02-08 July, 2018
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Proceedings Paper
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STEF92 Technology
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International Multidisciplinary Scientific GeoConference-SGEM
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Bulgarian Acad Sci; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci & Arts; Slovak Acad Sci; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; World Acad Sci; European Acad Sci, Arts & Letters; Ac
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83-90
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02-08 July, 2018
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website
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cdrom
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1778
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biofunctionalized nanoparticles; autoimmune diseases; diagnostic assay;
rheumatoid arthritis |
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