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Title: THE INFLUENCE OF COMPLEXATION WITH HYDROXYPROPYL-?-CYCLODEXTRIN AND SURFACTANTS ON THE DISSOLUTION PROFILE OF AMIODARONE HYDROCHLORIDE
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THE INFLUENCE OF COMPLEXATION WITH HYDROXYPROPYL-?-CYCLODEXTRIN AND SURFACTANTS ON THE DISSOLUTION PROFILE OF AMIODARONE HYDROCHLORIDE
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1314-2704
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English
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17
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61
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The objective of the study was to increase the solubility of amiodarone hydrochloride by complexation with hydroxypropyl-?-cyclodextrin. After complexation a cyclodextrin/amiodarone inclusion complex was formed. The use of media containing surfactants is a suitable solubilizing method and as a result, a non-ionic surfactant - Tween 80 and an anionic one - sodium lauryl sulfate have been used. The dissolution profile of amiodarone hydrochloride and that of the inclusion complex, regarding the release of the active substance, with or without surfactants was carried out in simulated physiological environment, at pH 1.2 (simulated gastric fluids) and pH 6.8 (simulated intestinal fluids). The dissolution test was carried out using two USP validated methods: paddle II apparatus dissolution test and Enhancer cell dissolution test.
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conference
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17th International Multidisciplinary Scientific GeoConference SGEM 2017
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17th International Multidisciplinary Scientific GeoConference SGEM 2017, 29 June - 5 July, 2017
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Proceedings Paper
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STEF92 Technology
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International Multidisciplinary Scientific GeoConference-SGEM
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Bulgarian Acad Sci; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci & Arts; Slovak Acad Sci; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; World Acad Sci; European Acad Sci, Arts & Letters; Ac
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375-382
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29 June - 5 July, 2017
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website
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cdrom
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4398
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amiodarone hydrochloride; surfactants; dissolution test.
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