HOME
Full Articles List
Search by Author
Title: RESEARCH AND EVALUATION OF RAT BLOOD INDICATORS AT REPEATED INHALATION EXPOSURE BY COPPER II OXIDE NANOPARTICLES AEROSOL
BibTex 
Open this article in the author's DB |
|
RESEARCH AND EVALUATION OF RAT BLOOD INDICATORS AT REPEATED INHALATION EXPOSURE BY COPPER II OXIDE NANOPARTICLES AEROSOL
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
1314-2704
|
|
|
|
||
|
|
English
|
|
|
|
21
|
|
|
|
7.2
|
|
|
|
• Prof. DSc. Oleksandr Trofymchuk, UKRAINE
• Prof. Dr. hab. oec. Baiba Rivza, LATVIA |
|
|
|
||
|
|
The blood parameters of rats under repeated inhalation exposure to copper oxide (II) nanoparticles aerosol (CuO NPs) compared to the microdispersed analogue (CuO MPs) have been studied and evaluated. According to the results of the study of the size, specific surface area, and total volume of pores, it was found that the sample under test is a nanomaterial. Rats were exposed to aerosols of aqueous suspensions of CuO NPs and CuO MPs for 10 days at 4 h/day in an inhalation system with a full-body chamber. The actual concentration in the chamber of CuO NPs was 1.17 ± 0.18 mg/m3, CuO MPs -1.39 ± 0.21 mg/m3. Twenty-four hours after the last exposure, 3 cm3 of blood wasdrawn from the tail vein to study biochemical and hematological parameters. Changesin biochemical and hematological blood parameters of rats exposed to nanomaterial inthe form of an increase in the activity of alanine aminotransferase (ALT), aspartateaminotransferase up to 2.2 times were noted, alkaline phosphatase, gamma-glutamyltranspeptidase (GGT), lactate dehydrogenase, amylase, antioxidant activity, increase ofC-reactive protein, malondialdehyde concentrations up to 1.39 times and decrease ofurea content by 1.41 times; increasing up to 5.4 times in the relative number ofeosinophils and leukocytes, the red blood cell distribution width, decreasing up to 1.4times of segmented neutrophils and monocytes. Rats exposed to CuO MPs showedsimilar changes in the studied indices, except for an increase in AST, GGT, and adecrease in the proportion of segmented neutrophils established when exposed to CuONPs. At the same time, the revealed 1.3-2.4-fold increase in some biochemical andhematological blood parameters of rats under the action of CuO NPs compared to CuOMPs indicates a more pronounced toxic effect of the studied nanomaterial on organs andsystems.
|
|
|
|
conference
|
|
|
|
||
|
|
||
|
|
21st International Multidisciplinary Scientific GeoConference SGEM 2021
|
|
|
|
21st International Multidisciplinary Scientific GeoConference SGEM 2021, 16 - 22 August, 2021
|
|
|
|
Proceedings Paper
|
|
|
|
STEF92 Technology
|
|
|
|
SGEM International Multidisciplinary Scientific GeoConference
|
|
|
|
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Serbian Acad Sci & Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts & Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci
|
|
|
|
39-46
|
|
|
|
16 - 22 August, 2021
|
|
|
|
website
|
|
|
|
cdrom
|
|
|
|
8288
|
|
|
|
copper II oxide; nanoparticles; microparticles; inhalation; toxicity
|
|
Download PDF