Title: BIOLOGICAL AND PHYSICOCHEMICAL PROPERTIES OF GOLD AND IRON NANOPARTICLES PRODUCED BY GREEN SYNTHESIS METHOD
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Title: BIOLOGICAL AND PHYSICOCHEMICAL PROPERTIES OF GOLD AND IRON NANOPARTICLES PRODUCED BY GREEN SYNTHESIS METHOD

BIOLOGICAL AND PHYSICOCHEMICAL PROPERTIES OF GOLD AND IRON NANOPARTICLES PRODUCED BY GREEN SYNTHESIS METHOD
Tsvetelina Batsalova; Dzhemal Moten; Ivan Butenko; Balik Dzhambazov; Alexander Vasil’kov
10.5593/sgem2022/6.1/s24.02
10.5593/sgem2022/6.1
1314-2704
978-619-7603-48-4
English
22
6.1
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Micro and Nano Technologies
Gold and iron nanoparticles were generated via environmentally safe metal-vapor synthesis method applying acetone or toluene as organic dispersion medium. Biological properties of the nanoparticles were analyzed by the agar disc diffusion method using Gram-positive and Gram-negative bacteria and via in vitro cytotoxicity assays with different human cell lines. The obtained results revealed distinct biological activity profiles of the studied specimens. Fe nanoparticles (Fe NPs) demonstrated inhibitory effects against both Gram-positive and Gram-negative bacteria. Au nanoparticles (Au NPs) produced in acetone as organic dispersion medium reduced the growth of E. coli, but showed lower activity against the Gram-positive bacterium B. cereus. Au NPs derived from toluene organosol demonstrated the lowest level of antibacterial activity. In vitro analyses with human cells indicated mild cytotoxic effects of Au NPs against all tested cell lines. Fe NPs demonstrated time- and concentration-dependent cytotoxicity against colon adenocarcinoma cells. Iron nanoparticles derived from acetone organosol did not induce negative effect on noncancerous human cells, which indicates a good biocompatibility potential. Their physicochemical properties were characterized by transmission and scanning electron microscopy (TEM, SEM), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). TEM observations demonstrated that Au NPs and Fe NPs have average sizes of 8.3 nm and 1.8 nm. Characteristics of the photoelectron spectra showed that gold is in the state of Au0, and the spectrum of iron is close in shape to the spectrum of Fe3O4.
gold nanoparticles, iron nanoparticles, cytotoxicity, antibacterial activity, metal-vapor synthesis
[1] Kharissova O.V., Dias H.V.R., Kharisov B.I., Olvera Perez B., Perez V.M.J., The greener synthesis of nanoparticles, Trends Biotechnol., vol. 31/issue 4, pp 240-248 2013.
[2] Narayanan K.B., Sakthivel N., Green synthesis of biogenic metal nanoparticles by terrestrial and aquatic phototrophic and heterotrophic eukaryotes and biocompatible agents, Adv. Colloid Interface Sci., vol. 169, pp 59–79, 2011.
[3] Rosi N.L., Mirkin C.A., Nanostructures in Biodiagnostics, Chem. Rev., vol. 105, pp 1547?1562, 2005.
[4] McNamara K., Tofail S., Nanoparticles in biomedical applications, Advances in Physics, vol. 2/issue 1, pp 54–88, 2017.
[5] Dykman L. A., Khlebtsov N. G., Gold nanoparticles in chemo-, immuno-, and combined therapy: review, Biomedical Optics Express, vol. 10/issue 7, pp. 3152-3182, 2019.
[6] Agarwal H., Nakara A., Shanmugam V.K., Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review, Biomedicine & Pharmacotherapy, vol. 109, pp 2561–2572, 2019.
[7] Aljarba N.H., Imtiaz S., Anwar N., Alanazi I. S., Alkahtani S., Anticancer and microbial activities of gold nanoparticles: A mechanistic review, Journal of King Saud University – Science, vol. 34, article 101907, 2022.
[8] Alangari A., Alqahtani M.S., Mateen A., Abul Kalam M., Alshememry A., Ali R., Kazi M., AlGhamdi K.M., Syed R., Iron Oxide Nanoparticles: Preparation, characterization, and assessment of antimicrobial and anticancer activity, Adsorption Science & Technology, vol. 2022, Article ID 1562051, 2022.
[9] Norouzi M., Yathindranath V., Thliveris J.A., Kopec B.M., Siahaan T.J., Miller D.W., Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles, Scientific Reports, vol. 10, 11292, 2020.
[10] Olenin A. Y.; Leenson I. A.; Lisichkin G. V., Cryochemical Co-condensation of Metal Vapors and Organic Compounds. In Direct synthesis of metal complexes; Kharisov, B. I., Ed.; Elsevier Inc: Netherlands, pp 143-149, 2018.
[11] Gerosa C., Crisponi G., Nurchi V.M., Saba L., Cappai R., Cau F., Faa G., Van Eyken P., Scartozzi M., Floris G., Fanni D., Gold Nanoparticles: A New Golden Era in Oncology?, Pharmaceuticals, vol. 13, 192; doi:10.3390/ph13080192, 2020.
[12] Vasil'kov A., Batsalova T., Dzhambazov B., Naumkin A., XPS study of silver and copper nanoparticles demonstrated selective anticancer, proapoptotic, and antibacterial properties. Surface and Interface Analysis, vol. 54/issue 3, pp. 189–202, 2022.
[13] Mmola M., Roes-Hill M.L., Durrell K., Bolton J.J., Sibuyi N., Meyer M.E., Beukes D.R., Antunes E., Enhanced antimicrobial and anticancer activity of silver and gold nanoparticles synthesized using Sargassum incisifolium aqueous extracts, Molecules, vol. 21/issue 12, 1633, 2016. https://doi.org/10.3390/molecules21121633
[14] Bai Aswathanarayan J., Rai Vittal R., Muddegowda U., Anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells, Artif Cells Nanomed Biotechnol, vol. 46/issue 7, pp. 1444–1451, 2018.
[15] Patil, M.P., Bayaraa, E., Subedi, P., Piad, L.L.A., Tarte, N.H., Kim, G.-D., Biogenic synthesis, characterization of gold nanoparticles using Lonicera japonica and their anticancer activity on HeLa cells, J. Drug Delivery Sci. Techn., vol. 51, pp 83–90, 2019.
The research was supported by the National Science Foundation of Bulgaria (project number KP-06-RUSSIA-14), Russian Foundation for Basic Research (project number 20-53-18006), Ministry of Science and Higher Education of the Russian Federation.
conference
Proceedings of 22nd International Multidisciplinary Scientific GeoConference SGEM 2022
22nd International Multidisciplinary Scientific GeoConference SGEM 2022, 04 - 10 July, 2022
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Turkish Acad Sci.
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