Peer-reviewed articles 17,970 +


Title: UV-VIS PHOTOCATALYTIC DEGRADATION OF CYCLOPHOSPHAMIDE ON NITROGEN DOPED TIO2 THIN FILM. KINETICS AND POSSIBLE DEGRADATION PATHWAY
UV-VIS PHOTOCATALYTIC DEGRADATION OF CYCLOPHOSPHAMIDE ON NITROGEN DOPED TIO2 THIN FILM. KINETICS AND POSSIBLE DEGRADATION PATHWAY

PlumX Article Metrics by Elsevier
Mirela Alina Constantin; Lucian-Alexandru Constantin; Arcadie Sobetkii; Florentina Laura Chiriac; Nicolae Ionut Cristea
10.5593/sgem2022/5.1/s20.065
10.5593/sgem2022/5.1
1314-2704
978-619-7603-46-0
English
22
5.1
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Ecology and Environmental Protection
Cyclophosphamide (CP) is a cytostatic drug prescribed at large scale, which proved to induce toxic effect on ecosystems and cannot be removed by conventional wastewater treatment processes. Therefore, there is a need to test advanced degradation processes for its removal from wastewater discharges. CP photocatalytic degradation via UV-VIS irradiation was studied using a Nitrogen -doped TiO2 catalyst. The catalyst was synthesized as thin film deposited on glass substrate under nitrogen atmosphere technique. The influence of N2 flow rate and annealing temperature on the CP degradation efficiency was investigated and best photocatalytic activity was obtained for catalyst with 1.8 %wt nitrogen content, synthesized at N2 flow rate=10 sccm, annealed at 550 oC for 1 hour. Its use assure the CP degradation with a pseudo-first order rate constant of 5.262 x 10-4 s-1 and an efficiency of 98 % for an irradiation time of 120. Based on the obtained experimental results in the presence of various scavengers it was found that superoxide radicals are representing the main oxidizing reactive specie involved in CP degradation, but contribution of free hydroxyl radicals from bulk solution is also possible. Degradation intermediates were identified using LC-MS and a possible degradation pathway consisting in three conversion routes was proposed.
[1] Nitoi I, Oancea P, Raileanu M, Crisan M, Constantin L, Cristea I., UV–VIS photocatalytic degradation of nitrobenzene from water using heavy metal doped titania, Journal of Industrial and Engineering Chemistry, vol 21, pp 677-682, 2015.
[2] Sato S, Nakamura R, Abe S., Visible-light sensitization of TiO2 photocatalysts by wet-method N doping, Applied Catalysis A: General, vol 284/issues 1-2, pp 131-137, 2005.
[3] Nosaka Y, Matsushita M, Nishino J, Nosaka AY., Nitrogen-doped titanium dioxide photocatalysts for visible response prepared by using organic compounds, Science and Technology of Advanced Materials, vol 6/issue 2, pp 143-148, 2005.
[4] Irie H, Watanabe Y, Hashimoto K., Nitrogen-concentration dependence on photocatalytic activity of TiO2-xNx powders, The Journal of Physical Chemistry B, vol 107/issue 23, pp 5483-5486, 2003.
[5] Kosowska B, Mozia S, Morawski AW, Grzmil B, Janus M, Kalucki K., The preparation of TiO2–nitrogen doped by calcination of TiO2 xH2O under ammonia atmosphere for visible light photocatalysis, Solar Energy Materials & Solar Cells, vol 88/issue 3, pp 269-280, 2005.
[6] Lai WW-P, Lin HH-H, Lin AY-C., TiO2 photocatalytic degradation and transformation of oxazaphosphorine drugs in an aqueous environment, Journal of Hazardous Materials, vol 287, pp 133-141, 2015.
[7] Wang M-C, Lin H-J, Wang C-H, Wu H-C., Effects of annealing temperature on the photocatalytic activity of N-doped TiO2 thin films, Ceramics International, vol 38/issue 1, pp 195-200, 2012.
[8] Cesen M, Kosjek T, Busetti F, Kompare B, Heath E., Human metabolites and transformation products of cyclophosphamide and ifosfamide: analysis, occurrence and formation during abiotic treatments, Environmental Science and Pollution Research, vol 23, pp 11209-11223, 2016.
This work was realized with the support of Operational Programme Competitiveness 2014 – 2020, Project ID P_40_300, SMIS 105581, Subsidiary Contract 6537/27.04.2018 and with the support of Ministry of Education and Research of Romania through Program Nucleu (project code PN 19 04 03 01)
conference
https://doi.org/10.5593/sgem2022/5.1/s20.065
Download PDF
Proceedings of 22nd International Multidisciplinary Scientific GeoConference SGEM 2022
22nd International Multidisciplinary Scientific GeoConference SGEM 2022, 04 - 10 July, 2022
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Turkish Acad Sci.
513-520
04 - 10 July, 2022
website
8729
Cyclophosphamide, degradation pathway, N-doped TiO2, photocatalysis, reactive species