Peer-reviewed articles 17,970 +



Title: DROSOPHILA MELANOGASTER AS A TEST-SYSTEM FOR ASSESSMENT OF THE AIR POLLUTION BY USING THE CITY OF KAZAN AS AN EXAMPLE

DROSOPHILA MELANOGASTER AS A TEST-SYSTEM FOR ASSESSMENT OF THE AIR POLLUTION BY USING THE CITY OF KAZAN AS AN EXAMPLE
Rustam Sokolov Viktoria Kostenko Tansu Gazieva Prof.DSc Natalya Stepanova
10.5593/sgem2023v/4.2
1314-2704
English
23
4.2
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Drosophila as a model for toxicological study is a simple and effective test-system owing to (i) availability of a wide range of accessible methods allowing the integral assessment of the negative effect of the factor under study on the vital characteristics at all levels of the organism vital activity (from molecular to population), (ii) possibility of obtaining results within a relatively short period of time (from 2 days to 2 weeks); (iii) low price of working methods, (iv) absence of specific requirements as to work with an object. The aim of the work was to assess the air quality in the city of Kazan based on the change of the drosophila’s vital parameters: the survival rate at the stage of embryogenesis, the fertility (the number of eggs), the locomotion, the degree of the intestines tissue damage and the level of DNA-comets. To analyze the air quality, we selected such city zones as, Privolzhsky (1), Moskovsky (2), Sovetsky (3). It was shown that flies that were in zones 1 and 2, but not in 3, are characterized by a decrease in fertility, an increase in embryonic death of offspring, intestines tissue damage and DNA damage.
[1] Lemos A. T., Coronas M. V., Mutagenicity of particulate matter fractions in areas under the impact of urban and industrial activities, Chemosphere, vol. 89, pp 1126–1134, 2012;
[2] Domingues E.P., Silva G. G., Genotoxic effects following exposure to air pollution in street vendors from a high-traffic urban area, Environ Monit Assess, vol. 190, p 215, 2018;
[3] Stepanova N., Valeeva E., The atmospheric air quality analysis and the health risk assessment for the Kazan city population (The Republic of Tatarstan), International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM, vol. 22, is. 5.1, pp 457–464, 2022;
[4] Gavrilova E., Kostenko V., Repression of Staphylococcus aureus and Escherichia coli by Lactiplantibacillus plantarum Strain AG10 in Drosophila melanogaster In Vivo Model, Microorganisms, vol. 11, is. 5, p 1297, 2023;
[5] Danilova A. L., Sukhomiasova A. L., Vital statistics and the crow index among the indigenous population of the Republic of Sakha (Yakutia), Ekologiya cheloveka (Human Ecology), vol. 28, N. 6, pp 12-20, 2021;
[6] Chambers, R. P., Call G. B., Nicotine increases lifespan and rescues olfactory and motor deficits in a Drosophila model of Parkinson’s disease, Behav. Brain Res. Vol. 253, pp 95–102, 2013;
[7] Sabat D., Patnaik A., Investigation of titania nanoparticles on behaviour and mechanosensory organ of Drosophila melanogaster, Physiol Behav, vol. 167, pp 76–85, 2016;
[8] Siddique, Y. H., Protective role of curcumin against the toxic effects of cyclophosphamide in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9, Alternative Medicine Studies, vol. 2, is. 1, p e2-e2, 2012;
[9] Mukhopadhyay I., Chowdhuri D. K., Evaluation of in vivo genotoxicity of cypermethrin in Drosophila melanogaster using the alkaline Comet assay, Mutagenesis vol. 19, pp 85–90, 2004;
[10] de Santana S. L., Vercosa C. J. Drosophila melanogaster as model organism for monitoring and analyzing genotoxicity associated with city air pollution, Environ Sci Pollut Res Int.;vol.25, is. 32, pp 32409-32417, 2018;
[11] Kim H., Kim W.- H., Air Pollution and Central Nervous System Disease: A Review of the Impact of Fine Particulate Matter on Neurological Disorders, Front. Public Health, vol. 8, p 575330, 2020;
[12] Maludze G; Stepanova N., Risk assessment of the incidence of cardiovascular diseases on the basis of evolutionary model, European Journal of Clinical Investigation, vol. 52, R. 20, 2022;
[13] Kennedy G. L., Arnold D., Mutagenic and teratogenic studies with lead acetate and tetraethyl lead, Toxicol Appl Pharmacol, vol. 19, pp 370-375, 1971;
[14] Alves C. A., Evtyugina M., Chemical profiling of PM10 from urban road dust, Sci Total Environ, vol. 634, pp 41–51, 2018;
[15] Billet S., Landkocz Y., Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells, J Environ Sci, vol. 71, pp 168–178, 2018;
[16] Nunez-Millacura C., Tapia V., An oxidative stress-mediated positive feedback iron uptake loop in neuronal cell, J Neurochem, vol. 82, pp 240–248, 2002;
[17] Eom, H.-J., Liu Y., Inhalation toxicity of indoor air pollutants in Drosophila melanogaster using integrated transcriptomics and computational behavior analyses. Sci. Rep., vol. 7, p 46473, 2017.
The work was performed in frames of the Kazan Federal University Strategic Academic Leadership Program (PRIORITY-2030).
conference
Proceedings of 23rd International Multidisciplinary Scientific GeoConference SGEM 2023
23rd International Multidisciplinary Scientific GeoConference SGEM 2023, 28-30 November, 2023
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference-SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Russian Acad Arts; Turkish Acad Sci.
183-190
28-30 November, 2023
website
9448
air pollution, genotoxicity, drosophila, adaptation