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Title: CYTOTOXIC EFFECT OF CHELIDONIUM MAJUS FREEZE DRYED EXTRACT: IN VITRO STUDY ON SKIN CANCER LINE
CYTOTOXIC EFFECT OF CHELIDONIUM MAJUS FREEZE DRYED EXTRACT: IN VITRO STUDY ON SKIN CANCER LINE

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Ramona Maria Romanu; Alina Anton; Maria Roberta Tripon; Cristina Dehelean; Camelia Tulcan
10.5593/sgem2023V/6.2/s25.15
10.5593/sgem2023v/6.2
1314-2704
978-619-7603-66-8
English
23
6.2
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Advances in Biotechnology
The multiple therapeutic properties of Chelidonium majus are known and well documented in the bibliography, being used for a long time in Chinese homeopathic medicine [1]. At the level of the skin, in traditional folk medicine, C. majus is used to treat warts, condylomas, and papillae, which are due to human papillomavirus (HPV) infections [2, 3]. In this context, the aim of this study was to assess the potential antitumor effects of C. majus extracts on human melanoma cells - A375 - and to evaluate it in terms of cell viability and morphology changes. Thus, an extract of C. majus (C_ex) was obtained in order to assess its potential antitumor effects. This extract was then tested on human melanoma cells - A375 - and evaluated in terms of cell viability and morphology changes. The results of the study highlighted the potential cytotoxic effect of C_ex on melanoma cells. It was observed that cell viability decreased in a dose-dependent manner after 24 hours. Moreover, the morphological changes are consistent with those observed following a cell viability test, exhibiting the characteristic signs of cell death.
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This research paper was conducted with technical support from the Antioxidant SystemsResearch Laboratory (A1c) team, part of the Institute for Biosafety and BioengineeringResearch (ICBB), University of Life Sciences “King Mihai I” from Timisoara as well asthe Pharmacological Research Center, Victor Babes University of Medicine andPharmacy, Timis? oara.
conference
https://doi.org/10.5593/sgem2023V/6.2/s25.15
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Proceedings of 23rd International Multidisciplinary Scientific GeoConference SGEM 2023
23rd International Multidisciplinary Scientific GeoConference SGEM 2023, 28-30 November, 2023
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference-SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Russian Acad Arts; Turkish Acad Sci.
117-123
28-30 November, 2023
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Chelidonium majus, plant extract, antitumor effect