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Title: SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES
SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES

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Dumitrela DIACONU; Violeta Mangalagiu; Dorina Amariucai-Mantu; Vasilichia Antoci; Ionel Mangalagiu
10.5593/sgem2023V/6.2/s25.45
10.5593/sgem2023v/6.2
1314-2704
978-619-7603-66-8
English
23
6.2
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Advances in Biotechnology
Sulfonamides are appropriate ligands for the preparation of coordination compounds with biological activity, as they possess bactericidal, antiviral, antidiabetic, and diuretic properties and some sulfonamide compounds are under clinical evaluation for cancer treatment. Metal complexes provide highly versatile platforms for drug design. Considering the biological potential of the quinoline nucleus, but also of the sulfonamide scaffold (especially antimicrobial), as well as that of the quinoline- sulfonamide combination we have decided to combine the two pharmacophore fragments. And at last, the complexation with divalent metals - M2+ (M2+: Zn2+, Cu2+, Co2+ and Cd2+) will bring complementary biological activity given by the cation with the final goal of achieving improved biological activity and better pharmacokinetic properties. The synthesized molecules were characterized by HRMS and NMR spectroscopy. The compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising.v
[1] Pozharskii, A.F., Soldatenkov, A., Heterocycles in Life and Society-AnIntroduction to Heterocyclic Chemistry, Biochemistry and Applications, Wiley,2011.
[2] Rocco F., The Miraculous Fever-Tree. The Cure that Changed the World, BritishMedical Journal, 327(7407), 649, 2003.
[3] Diaconu, D., Antoci, V., Mangalagiu, V., Amariucai-Mantu, D., Mangalagiu, I.I.Quinoline - imidazole/benzimidazole derivatives as dual- / multi- targeting hybridsinhibitors with anticancer and antimicrobial activity. Scientific Reports 12, 16988,2022.
[4] Antoci, V.; Cucu, D.; Zbancioc, Ghe.; Moldoveanu, C.; Mangalagiu, V.Amariucai-Mantu, D.; Aricu, A.; Mangalagiu, I.I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. Part XII,Future Medicinal Chemistry 12(3), 207-222, 2020.
[5] Popovici, L.; Amarandei, R.M.; Mangalagiu I.I.; Mangalagiu, V.; Danac, R.:Synthesis, molecular modelling and anticancer evaluation of new pyrrolo
[1,2-b]pyridazine and pyrrolo
[2,1-a]phthalazine derivatives, Journal Of EnzymeInhibition And Medicinal Chemistry, 34(1), 230-243, 2019.
[6] Luca, M.C, Tura, V; Mangalagiu I.I. Considerations concerning design andmechanism of action of a new class of dual DNA intercalators, Medical Hypotesis,75, 627-629, 2010.
[7] Sen, C., Sahoo, T., Singh, H., Suresh, E., Ghosh, S.C., Visible light-promotedphotocatalytic C-5 carboxylation of 8-aminoquinoline amides and sulfonamides viaa single electron transfer pathway, The Journal of Organic Chemistry, 84(16),9869-9896, 2019.
[8] Pascual-Alvarez, A., Topala, T., Estevan, F., Sanz, F., Alzuet-Pina, G.,Photoinduced and self-activated nuclease activity of copper(II) complexes withN-(quinolin-8-yl)quinolin-8-sulfonamide – DNA and bovine serum albuminbinding, European Journal of Inorganic Chemistry, 2016(7), 982 – 994, 2016.
[9] Da Silva, L.E., Joussef, A.C., Pacheco, L.K., Da Silva, D.G.., Steindel, M., Rebelo,R.A, Schmidt, B. Synthesis and in vitro evaluation of leishmanicidal andtrypanocidal activities of N-quinolin-8-yl arylsulfonamides, Bioorganic &Medicinal Chemistry, 15, 7553-7560, 2007.
[10] Diaz, J.R.A., Baldo, M.F., Echeverria, G., Baldoni, H., Vullo, D., Soria, D.B.,Supuran, C.T., Cami, G.E., A substituted sulfonamide and its Co(II), Cu(II), andZn(II) complexes as potential antifungal agents, Journal of Enzyme Inhibition andMedicinal Chemistry, 31(2), 51-62, 2016.
[11] Diaconu, D., Mangalagiu, V., Dunca, S., Amariucai-Mantu, D., Antoci, V., Roman,T., Mangalagiu, I.I., Ultrasound assisted synthesis of hybrid quinoline anchoredwith 4-R-benzenesulfonamide moiety with potential antimicrobial activity,Heliyon, 9, e21518, 2023.
[12] Zhong, F., Geng, G., Chen, B., Pan, T., Li, Q., Zhang, H., Bai, C. Identification ofbenzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitorstargeting Rev protein, Organic and Biomololecular Chemistry, 13( 6), 1792 – 1799,2015.
[13] Pascual-Alvarez, A., Topala, T., Estevan, F., Sanz, F., Alzuet-Pina, G.,Photoinduced and self-activated nuclease activity of copper(II) complexes withN-(quinolin-8-yl)quinolin-8-sulfonamide – DNA and bovine serum albuminbinding, European Journal of Inorganic Chemistry, 2016(7), 982 – 994, 2016.
[14] Diaconu, D., Mangalagiu, V., Amariucai-Mantu, D., Antoci, V., Giuroiu, C.L.,Mangalagiu, I.I., Hybrid quinoline-sulfonamide complexes (M2+) derivatives withantimicrobial activity, Molecules, 2(12), 2946, 2020.
This work was co-funded by the European Social Fund, through OperationalProgramme Human Capital 2014-2020, project number POCU/993/6/13/153322,project title << Educational and training support for PhD students and youngresearchers in preparation for insertion into the labor market >>. Authors are alsothankful for financial support to CNCS-UEFISCDI, project number PN-III-P4-IDPCE-2020-0371.
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Proceedings of 23rd International Multidisciplinary Scientific GeoConference SGEM 2023
23rd International Multidisciplinary Scientific GeoConference SGEM 2023, 28-30 November, 2023
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference-SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Russian Acad Arts; Turkish Acad Sci.
369-375
28-30 November, 2023
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hybrid compounds, quinoline, sulfonamide.