Peer-reviewed articles 17,970 +


Dr. Simona Marc; Dr. Cristina Paul; Dr. Eng. Oana Maria BOLDURA; Dr. Jelena SAVICI; Dr. Gabriel OTAVA
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Hypospadias is a developmental abnormality in which the male urethra opens on the underside of the penis or on the perineum and can be accompanied by penile aplasia or hypoplasia, hypoplasia of the corpus cavernosum, incomplete formation of the prepuce, or cryptorchidism [1]. In animals, it rarely appears in horses, sheep, goats, cattle, dogs, and cats as isolated cases with urogenital anomaly or with other abnormalities [2,3]. The aim of this paper is to present the hystological results in a crossbred calf seen with anterior hypospadias with syndromic evolution. Clinically, the penile urethra ventrally opened at approximately 4 cm caudal of the normal opening of the urethra, also, the prepuce was incompletely developed and had failed to fuse normally. The Hematoxylin-Eosin method was used for hystological examination of the urethra. Microscopically, the urethra wall was composed of mucosa with epithelium and lamina propria, vascular layer, thin muscle layer, and adventitia, a lax connective tissue. The formation that should be the corpus cavernosum was separated from the body of the corpus spongiosum and urethra. In the center of the structure there was a connective tissue strand made of converging trabeculae. However, between the trabeculae, where the cavernous spaces should be, there was an abundance of monolocular adipocytes. In conclusion, histological examination revealed the normal structure of the urethra with adipose degeneration into the corpus cavernosum.
[1] Pineyro-Ruiz C., Serrano H., Perez-Brayfield M.R., Jorge J.C., New frontiers on themolecular underpinnings of hypospadias according to severity, Arab Journal of Urology2020, 18, pp. 257-266.
[2] Iannuzzi A., Braun M., Genualdo V., Perucatti A., Reinartz S., Proios I., HeppelmannM., Rehage J., Hulskotter K., Beineke A., Metzger J., Distl O., Clinical, cytogenetic andmolecular genetic characterization of a tandem fusion translocation in a male Holsteincattle with congenital hypospadias and a ventricular septal defect, Plos One, 2020, 15(1),pp. 1-21.
[3] Usta Z.D., Ottmar Atresia Ani, Hypospadia and Rudimentary External Genitalia inTwo German Holstein Calves, Ataturk Universitesi Vet. Bil. Derg. 2017, 12, pp. 195-202.
[4] Hristov K., Stoimenov A., Hypospadias in small ruminants: a case report. Traditionand Modernity in Veterinary Medicine 2020, 5, pp. 58-61, doi:10.5281/zenodo.3675514.
[5] Chang J., Wang S., Zheng Z., Etiology of Hypospadias: A Comparative Review ofGenetic Factors and Developmental Processes Between Human and Animal Models. ResRep Urol 2020, 12, pp. 673-686, doi:10.2147/RRU.S276141.
[6] van der Zanden L.F.M., van Rooij I.A.L.M,; Feitz W., Franke B., Knoers, N.V.A.M.,Roeleveld N., Aetiology of hypospadias: a systematic review of genes and environment.Human reproduction update 2012, 18, 3, pp. 260-283.
[7] Harrison J., Corley K., Kearney C., Mushtaq I., Single stage urethroplasty for perinealhypospadias in a foal, Equine Vet Educ, 2018, 30, 10, pp. 527-530,
[8] Hoque M., A Case Report on Surgical Management of Hypospadias in a Day-OldGoat Kid, International Journal of Livestock Research, 2021, 11, 2, pp. 175-178, 4808.
[9] Switonski M., Dzimira S., Aleksiewicz R., Szczerbal I., Nowacka-Woszuk J.,Krzeminska P., Deska T., Nizanski W., Hypospadias Is Not Rare in Dogs: Five NewCases, a Retrospective Study, and a Review of the Literature. Sexual Development 2018,12, pp. 244-250, doi:10.1159/000490079.
[10] Meyers-Wallen V.N., Gonadal and sex differentiation abnormalities of dogs andcats. Sex Dev, 2012, 6, pp. 46-60, doi:10.1159/000332740.
[11] Krzeminska P., D'Anza E., Ciotola F., Paciello O., Restucci B., Peretti V., AlbarellaS., Switonski M., Polymorphisms of MAMLD1, SRD5A2 and AR Candidate Genes inSeven Dogs (78,XY; SRY-Positive) Affected by Hypospadias or Cryptorchidism. SexualDevelopment 2019, 13, pp. 92-98, doi:10.1159/000500219.
[12] Snodgrass W., Patterson K., Plaire J.C., Grady R., Mitchell M.E., Histology of theurethral plate: implications for hypospadias repair, Journal of Urology, 2000, 164, 3, pp.988-990, DOI: 10.1097/00005392-200009020-00017.
[13] van der Putte S.C.J, Hypospadias and associated penile anomalies: ahistopathological study and a reconstruction of the pathogenesis, Journal of Plastic,Reconstructive & Aesthetic Surgery, 2007, 60, 1, pp. 48-60,
[14] Sennert M., Perske C., Wirmer J., Fawzy M., Hadidi A.T., The urethral plate and theunderlying tissue; a histological and histochemical study, J Pediatr Urol, 2022, 18, 3, doi:10.1016/j.jpurol.2022.02.006.
[15] Marc S., Mizeranschi A.E., Paul C., Otava G., Savici J., Sicoe B., Torda I., Hu?u I.,Mircu C., Ilie D.E, Caraba? M., Boldura O.M., Simultaneous Occurrence of Hypospadiasand Bilateral Cleft Lip and Jaw in a Crossbred Calf: Clinical, Computer Tomographic,and Genomic Characterization, Animals, 2023, 13, 1709,
Proceedings of 23rd International Multidisciplinary Scientific GeoConference SGEM 2023
23rd International Multidisciplinary Scientific GeoConference SGEM 2023, 28-30 November, 2023
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference-SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Russian Acad Arts; Turkish Acad Sci.
28-30 November, 2023
hypospadias, congenital abnormalities, syndromic evolution, urethra