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BIOMARKERS OF ORAL EXPOSURE THROUGH DRINKING WATER N-NITROSAMINES, ALIPHATIC CHLORINATED ORGANIC COMPOUNDS
Abstract
To prove adverse impacts exerted by drinking water and to assess regularities in occurrence of health disorders caused by contamination burden on the body, experts from the Center performed complex chemical-analytical and medical-biological examinations of children who lived on an exposed territory and consumed drinking water with chemical contents exceeding hygienic standards: N-nitrosodimethylamine, by 1.6 times; chloroform, by 5 times; dichlorobrommethane, by 26 times; and children who lived on a reference territory where quality of drinking water conformed to hygienic standards. Results of the accomplished examinations confirmed that long-term exposure to N-nitrosodimethylamine and chloroform through drinking water resulted in elevated concentrations of these substances in blood of children from the test group since N-nitrosodimethylamine contents were by 3.3 times higher and chloroform contents were by 5.6 times higher in their blood than in the reference group. To prove risks caused by exposure to the examined substances and to substantiate exposure markers, we performed studies aimed at establishing a correlation within “toxicant concentration in blood – toxicant concentration in drinking water” system based on components of risk assessment methodology. Modeling allowed revealing that changes in N-nitrosodimethylamine and chloroform concentrations in blood followed the dependences N-nitrosodimethylamine concentration in blood - N-nitrosodimethylamine concentration in drinking water and chloroform concentration in blood – chloroform concentration in drinking water. Therefore, N-nitrosodimethylamine and chloroform concentrations in blood can be used as markers of oral exposure through drinking water.
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