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LACTATE DEHYDROGENASE ENZYME AND ITS IMPLICATIONS IN CHEMICAL STRESS SITUATIONS

Assoc. Prof. Laur Manea, PH. Roger Manea, Prof. Ole Martin Eklo

First published: 2017-06-20https://doi.org/10.5593/sgem2017/61/s25.102View metrics

Abstract

Enzymes are major components of organism defense against toxic chemicals in their environment. Despite the passage of more than 200 million years of life presence these enzymes now play an important role in detoxifying chemicals man-made addiction and it may be a useful biomarker. Lactate dehydrogenase (LDH or LD) is intracellular enzyme year found early in all living cells (animals, plants, and prokaryotes). LDH catalyzes the conversion of pyruvic acid to lactic acid and back, as it converts NAD + to NADH and back. A dehydrogenase enzyme transfers a hydride from one molecule to another. LDH enzyme exists in four distinct classes: first is NAD (P) -dependent L-lactate dehydrogenase; other LDHs act on D-lactic and / or is dependent on cytochome C: Dlactate dehydrogenase (cytochome) and L-lactate (L-lactate dehydrogenase (cytochome). LDH is expressed extensively in body tissues, such as blood cells and heart muscle. Lactate dehydrogenase (LDH) is widely distributed throughout the body, as seen mainly in the kidney, myocardium, skeletal muscle, brain, liver and lungs. Because it is released during tissue damage, it is a marker of common injuries such as heart failure and disease.

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Publication details

Title
LACTATE DEHYDROGENASE ENZYME AND ITS IMPLICATIONS IN CHEMICAL STRESS SITUATIONS
Authors
Assoc. Prof. Laur Manea, PH. Roger Manea, Prof. Ole Martin Eklo
Proceedings
SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings; 17th International Multidisciplinary Scientific GeoConference SGEM2017, Nano, Bio and Green - Technologies for a Sustainable Future
Publisher
STEF92 Technology
Year
2017
Pages
783-790
SWS Citekey
Manea201725783790
ISSN
1314-2704
ISBN
978-619-7408-12-6
Language
en
Publication type
Conference Paper
Keywords
lactate dehydrogenasechemicalsbiomarkerinjuriestissue
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