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EFFECT OF TECHNOLOGICAL PARAMETERS ON ELECTROSPINNABILITY OF WATER-ORGANIC SOLUTIONS OF HYALURONIC ACID
Abstract
Hyaluronic acid (HA) is rightfully considered as a promising and advanced polymer for development and producing a variety of applications in medicine, biotechnology and tissue engineering. One such trend is electrospun fiber materials obtained from HA solutions. However, HA has absolutely highly resistance to volatile organic solvents (such solvents are strongly encouraged for utilizing in case of electrospinning), that make the obtaining of polymer fibers difficult. Despite this, some authors could elaborate nanofibers based on HA from the aqueous-organic solutions, for instance, dimethyl formamid (DMF)/water solvent mixtures, but in the context of biomaterials utilizing DMF is prohibited. In addition, several studies describe fiber materials obtained from HA and carrier polymers such as polyvinyl alcohol (PVA) or polyethylene oxide (PEO). Having said that, utilizing such polymers notably decreases biomedical worth of native HA. This study describes the primary results of obtaining polymer structures via electrospinning from the HA solutions based on water and dimethyl sulfoxide/water systems without modifying polymers. Moreover, in this paper, the impact assessment of technological parameters on electrospinnability of spinning solutions was carried out. This finding is expected to broad the application of the electrospinning micro- and nanofibers from biopolymers for the development of modern materials.
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References12
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