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MEDICINAL FUNGI OF THE GENERA OPHIOCORDYCEPS SINENSIS AND PAECILOMYCES HEPIALI
Abstract
Various secondary metabolites isolated from Ophiocordyceps sinensis, the Chinese caterpillar fungus, have been reported to possess high therapeutic potential. Paecilomyces hepiali has even more biologically important chemical components with interesting pharmacological activity. Traditional Chinese medicine uses Ophiocordyceps sinensis to treat lung and respiratory system problems, hyposexuality, hypolipidemia kidney, or liver, heart, and immune system conditions. In addition, it has been used to treat various forms of cancer, especially in addition to chemotherapy and radiotherapy. The objective of the present study was to determine the antioxidant activity of metabolites isolated from medicinal fungi of the genera Ophiocordyceps sinensis and Paecilomyces hepiali cultivated on two types of rice (Oryza sativa var. indica and Oryza sativa var. japonica). Antioxidant activity was determined by applying the 1,1-diphenyl-2-picrylhydrazyl radical scavenging method to alcoholic extracts of O. sinensis and P. hepiali strains. Samples were prepared using reflux extractions. Refluxing produced the highest extraction yield. The highest extraction yield was achieved for the O. sinensis (4OS, 9.86 %) sample grown on Oryza sativa var. japonica. The highest scavenging ability for the stable 1,1-diphenyl-2-picrylhydrazyl radical was observed for the extract of Paecilomyces hepiali cultivated on Oryza sativa var. japonica (Sample 5PH: IC50DPPH 3.03 mg/mL). The chemical structure of the alcohol extracts was determined by NMR spectroscopy. Unsaturated fatty acids (Z-oleic acid, linoleic acid and D-mannitol) were identified as the major components of the extracts.
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