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STUDY OF THE EFFECT OF THE OXIDANT CONTENT ON THE PROPERTIES OF GELATIN / TANNIN-BASED HYDROGEL
Abstract
The problem of obtaining compositions, that would act as biomaterials and fit all demands, is well-known. One the branch of application materials such is the hydrogels. High retention capacity of water and physiological fluids, sufficient physio-mechanical properties and safety of usage are ones of the most relevant specifications for medical hydrogels. It is quite hard to develop such formulations. Perspective initial substances for synthesis are gelatin (peptide native to human collagen) and tannin (natural compound with anti-inflammatory properties). It is necessary to oxidize tannin before it can act as crosslinker in a hydrogel formation. All among plenty of oxidative agents it is difficult to find out appropriate one, which could effectively support oxidation, but would not cause harmful decay byproducts and further toxic influence on human body. The objective of that research was to gain and study the impact of oxidizers on properties of hydrogel compositions. There were obtained hydrogels of gelatin crosslinked by oxidized tannin in that study. This work was investigated the sorption behavior and properties of materials in solution with different pH. The work also studied the effect of oxidants (H2O2; DMSO) with different molar ratios to tannin on the sorption properties of the obtained hydrogels. There were studied thermal properties using TGA and structure of compositions by IR spectroscopy. It was found that better sorption properties and thermal stability were achieved by using hydrogen peroxide in 0.7-0.8 mole ratio.
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Buwalda S.J., Vermonden T., Hennink E.M. Hydrogels for therapeutic delivery: current developments and future directions, Biomacromolecules, V. 18 (2), 2016, pp. 316-330. DOI: 10.1021/acs.biomac.6b01604
Wang X., Yang, Y., Shi, Y., Jia, F. Smart Hydrogels in Tissue Engineering and Regenerative Medicine. Lausanne: Frontiers Media SA, 119 p., 2020. DOI: 10.3389/978-2-88963-765-2
Uspenskaya M.V., Ignatyeva J.A., Kasanov K.N., Olekhnovich R.O., Strelnikova I.E. Wound dressing on the base of polymer nanocomposites, IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", 2014, Article number 7047523, Pages 369-372. DOI: 10.1109/IECBES.2014.7047523.
Reddy N., Reddy R., Jiang Q. Crosslinking biopolymers for biomedical applications. Trends in biotechnology, V. 33 (6), 2015, pp. 362-369. DOI: 10.1016/j.tibtech.2015.03.008
Ajovalasit A., Sabatino M.A., Todaro S., Alessi S., Giacomazza D., Picone P., Carlo M.D., Dispenza C. Xyloglucan-based hydrogel films for wound dressing: structure-property relationships. Carbohydrate polymers, V. 179 (1), 2018, pp. 262-272. DOI: 10.1016/j.carbpol.2017.09.092
Wang L., Stegemann J.P. Glyoxal crosslinking of cell-seeded chitosan/collagen hydrogels for bone regeneration. Acta Biomaterialia, V. 7 (6), 2011, pp. 2410-2417. DOI: 10.1016/j.actbio.2011.02.029
Song F., Zhang L., Yang C., Yan L. Genipin-crosslinked casein hydrogels for controlled drug delivery. International Journal of Pharmaceutics, V. 373, 2009, pp. 41–47. DOI: 10.1016/j.ijpharm.2009.02.005
Boonkaew B., Suwanpreuksa P., Cuttle L., Barber P.M., Supaphol P. Hydrogels Containing Silver Nanoparticles for Burn Wounds Show Antimicrobial Activity Without Cytotoxicity. J. Appl. Polym. Sci., V. 131, 2014, p. 40215. DOI: 10.1002/app.40215
Penaranda J.E., Sabino M.A. Effect of the presence of lignin or peat in IPN hydrogels on the sorption of heavy metals. Polym. Bull., V. 65, 2010, pp. 495–508. DOI: 10.1007/s00289-010-0264-3
Plazinski W., Rudzinski W., Plazinska A. Theoretical models of sorption kinetics including a surface reaction mechanism: A review. Advances in Colloid and Interface Science, V. 152, 2009, pp. 2–13. DOI: 10.1016/j.cis.2009.07.009
Poncet-Legrand C., Cabane B., Bautista-Ort?n A., Carrillo S., Fulcrand H., P?rez J., Vernhet A. Tannin Oxidation: Intra- versus Intermolecular Reactions. Biomacromolecules, V. 11 (9), 2010, pp. 2376–2386. DOI: 10.1021/bm100515e
Tidwell T.T. Oxidation of Alcohols by Activated Dimethyl Sulfoxide and Related Reactions: An Update. Synthesis, V. 10, 1990, pp. 857-870. DOI: 10.1055/s-1990-27036
Zhao Q., Mu S., Long Y., Zhou J., Chen W., Astruc D., Gaidau C. Gu H. Tannin-Tethered Gelatin Hydrogels with Considerable Self-Healing and Adhesive Performances. Macromolecular materials and engineering, V. 304 (4), 2019, p. 1800664. DOI: 10.1002/mame.201800664
John A.D. Handbook of chemistry. New-York: McGraw-Hill, inc., 1561 p., 1999.
Zhao Q., Mu S., Liu X., Qiu G., Astruc D., Gu H. Gallol-Tethered Injectable AuNP Hydrogel with Desirable Self-Healing and Catalytic Properties. Macromol. Chem. Phys., V. 220, 2019, p. 1800427. DOI: 10.1002/macp.201800427
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