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A STUDY ON THE OPTIMIZATION OF STRUCTURAL CHARACTERISTICS OF SOME SILICATE MATRICES BY AMINO-FUNCTIONALIZATION

Assoc. Prof. Dr. Lacramioara Ochiuz, Prof. Dr. Eugen Diug, Assoc. Prof. Dr. Diana Guranda, Dr. Cristian Grigoras, Lecturer Dr. Maria Ignat

First published: 2017-06-20https://doi.org/10.5593/sgem2017/61/s24.002View metrics

Abstract

Mesoporous silica nanoparticles have recently attracted researchersпїЅ attention by opening a new perspective on the development of new drug delivery systems. Such mesoporous materials are characterized by a uniform distribution of pore size, welldefined walls with a high volume that enables functionalization at the level of silanol group, having a large specific surface and good hydrothermal stability. The objective of this study is the synthesis and characterization of MCM -48 and KIT-6 silicate matrices, biomaterials with 3D cubic structure of pores and optimal functionalization and drug loading properties. Both materials are cubic, highly ordered, presenting a threedimensional pore system with surface size and chemistry adjustable by functionalization according to the aim pursued. In the case of KIT-6 mesoporous silica, pore dimension can also be adjusted by altering the synthesis temperature, thus providing an additional way to control drug substance loading and release. The structural and textural assessment of silica samples was performed by specific methods such as X-ray diffraction, nitrogen adsorption-desorption, Fourier Transform Infrared spectroscopy and TEM technique.

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Title
A STUDY ON THE OPTIMIZATION OF STRUCTURAL CHARACTERISTICS OF SOME SILICATE MATRICES BY AMINO-FUNCTIONALIZATION
Authors
Assoc. Prof. Dr. Lacramioara Ochiuz, Prof. Dr. Eugen Diug, Assoc. Prof. Dr. Diana Guranda, Dr. Cristian Grigoras, Lecturer Dr. Maria Ignat
Proceedings
SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings; 17th International Multidisciplinary Scientific GeoConference SGEM2017, Nano, Bio and Green - Technologies for a Sustainable Future
Publisher
STEF92 Technology
Year
2017
Pages
11-18
SWS Citekey
Ochiuz2017241118
ISSN
1314-2704
ISBN
978-619-7408-12-6
Language
en
Publication type
Conference Paper
Keywords
mesoporous silica matricesbiomaterialsamino-functionalization
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