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THE STUDY OF WOUND-HEALING ACTIONS OF COLLAGEN MEMBRANES WITH PROBIOTICS FOR TOPICAL APPLICATION

Moldir Koilybayeva

Abstract

Background. The issues wound-healing is relevant to the present. Wound-healing is a complex process which involves the accumulation of fibroblasts in the dermal damage zone, the synthesis of scleroproteins, wound retraction, epithelization. A promising direction of research is the creation of application prolonged dosage forms of transdermal appointment based on synthetic polymers and natural origin. At this point, a natural polymer collagen can be considered the most promising raw material in the development of such drugs for topical use. It should be noted that immobilization of known drugs and biologically active agents on collagen provides prolongation of their action, reduces toxicity, reduces local irritant reaction, increases therapeutic activity. Probiotics as a new class of therapeutic and prophylactic drugs are now increasingly used in medical practice and indications for their use are increasingly expanding and represent a heterogeneous group of non-pathogenic bacteria. As noted above, a significant place in the infectious pathology of people occupy purulent-inflammatory diseases of the skin and mucous membranes, which often develop as a result of their traumatic injuries (wounds, burns). Treatment of such injuries with antibiotics and other traditional means is not always effective, so the task of combating inflammatory diseases of the external cover is currently relevant and requires new solutions. This circumstance served as the basis for theoretical and experimental studies to assess the possibility of developing new pharmacological preparations for external use on the basis of already known probiotics and modern transdermal bases. Methods. The article presents the results of studies of the wound-healing effect of collagen membranes with probiotics. Toxicological studies were performed to test of membrane toxicity studies on white mice and test of studying the local irritant effect on mucous membraneson rabbits. The wound-healing effect of membranes was studied on Guinea pigs based on the model of conditionally pure wounds. Results and discussion. In the application ofcollagen membranes did not observe the death of animals throughout the experience. The general condition of animals, which exposed to chronic membrane exposure did not differ from the control animals. Skin of experimental and control animals had the same manner, signs of irritation in all groups were absent. The significant physiological differences between control and experimental groups of animals were not found. The weight coefficients of internal organs also did not differ from the control. The autopsy did not reveal any abnormalities in the structure of organs and of serous membranes. Microscopic studies have shown no fundamental differences between experience and control. Conclusion. Biomembranes with probiotics have a pronounced wound-healing effect, and are characterized by complete epithelization of the burn defect and a shrinking in the time of healing.

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DOI resolver: doi.org/10.5593/sgem2018/6.2/s25.100

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