Scholarly record

NEW SYNTHESES OF COMPOUNDS WITH ANTIDEPRESSANT ACTION

Alina Ştefanache

Abstract

Treating depression is a complex process, which includes medical treatment and also psychotherapeutic approach. These two approaches are working together. There is a large scale of known treatments for depressive disorders, which had been developed since the 1950s and the therapeutic effectiveness and patient tolerance were assessed through generations. Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been Among the studied variants, anorganic products had been underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, underlined and the lithium derivatives had shown best results. Our days, pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes pharmacology is focused on lithium as it influences cellular and molecular processes through a my through a my through a my through a mystery still unknown fo stery still unknown fostery still unknown fostery still unknown fo stery still unknown fo stery still unknown fo stery still unknown for modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. r modern science and yet to be discovered. Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed Thus, in a previous work, the authors proposed some used and functionalized aminosulphonyl-clor-phenoxi-acetics acids and them lithium salts. The main objective of this research is the obtaining the other lithium salts of the aminosulfonyl-chlorine-phenoxyacetic acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, common acids and functionalized acids, unquoted in literature, with anti depressive potential and reduced toxicity. Specific objectives are design and synthesis of the aminosulfonyl-chlorine-phenoxyacetic acids? lithium salts; synthesis and purification of the aminosulfonyl-chlorine-phenoxyacetic acids; synthesis and purification of the aminosulfonyl-chlorine-phenoxyacetic acids? lithium salts. Structure confirmation of the new synthesised compounds through modern spectral analyses (FT -IR , UV/VIS, RMN, SM) and after are going to be studied in vitro and in vivo in order to obtain their pharmaceutical characterization and anti depressive effects. For each synthesis phase, the optimal reaction conditions are going to be set (temperature, reaction time, utilised environment, catalysers) for obtaining final products endowed with high effectiveness and purity. Purifying the compounds is an important phase and it is realised through processes of recrystallisation, extraction and chromatography.The characterised products are going to be subjected to pharmacological evaluation. The researches novelty from this study consist, on one hand, of the new salts? synthesis with anti depressive effect, unquoted in the literature and on the other, the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity.the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity.the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity.the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity.the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity.the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity. the products synthesized exhibit antidepressant activity.the

Publication Impact Profile

• Captures
• Mendeley - Readers: 1

PLUMX see details

DOI resolver: doi.org/10.5593/sgem2019/6.1/s24.042

Publication details

Back to publication list