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ULTRATHIN MEMBRANES FOR ESTABLISHMENT OF PHYSIOLOGICALLY RELEVANT CELL BARRIERS. FOCUS ON BLOOD-BRAIN BARRIER
Abstract
The thickness of the blood-brain barrier (BBB) basement membrane (BM) in vivo is in the range of 20 - 200 nm. Most widely used commercially available microporous polycarbonate (PC), polyethylene terephthalate (PET) or polytetrafluoroethylene (PTFE) membranes are 10 to 50 ?m thick. This is a substantial obstacle for communication of cells growing on both sides of membrane, like astrocytes, pericytes and endothelial cells within in vitro BBB model. For the last several years the active development of ultrathin microporous membranes is in progress. As an example, are ultrathin ceramic or polymeric nanomembranes 100 - 500 nm thick. Geometrical parameters of such artificial nanomembranes are close to the characteristics of in vivo basement membranes. However, to the date commercially available products integrated into standard cell culture vessels or microfluidic systems are almost absent. This review focuses on description of existing developments in the field of ultrathin membranes suitable for establishment of cell barriers.
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