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ANTHROPOGENIC PRODUCTION FACTORS, FEATURES OF IMMUNITY AND POLYMORPHISM GENES, AS A CONDITION OF THE FORMATION OF ATHEROSCLEROSIS, COMPLICATED BY HYPERTENSION
Abstract
Anthropogenic factors of the production environment of oil production are characterized by more intensive influence of these factors in contrast to the external environment, which can create the prerequisites for early development of adaptation disorders, functional changes in immune and humoral regulation, especially with their genetic determinism, and the formation of an increased risk of development and weighting of cardiovascular pathology in those engaged in oil production. The aim of the work was to study the features of immunological health of those working in the conditions of exposure of man-made production factors of oil production (oil and gas production operators) with the established pathology of the cardiovascular system (atherosclerosis), associated with polymorphism of candidate genes. To achieve this goal, the molecular markers of apoptosis were analyzed using the flowing cytometry method. The level of specific sensitization according to the IgG criterion to benzene was assessed using the immunoenzymometric analysis method. Analysis of single-nucleotide polymorphism (SNP) candidate genes ADRB2 (rs1042317), ANKK1(rs1800497), NR3C1 rs6195 and CYP1A1 (rs1048943) was conducted using the PCR technique in real time. It was found that the immune status of oil production enterprises workers under the conditions of exposure to anthropogenic production factors with established cardiovascular pathology differs significantly (p<0.05) by an increased level of specific sensitivity according to the criterion of specific IgG to benzene and excess cell death, as evidenced by an increase (p<0.05) in the expression level of CD3+CD95+-a marker of lymphocytes, Pro-apoptotic proteins p53 and Bax, as well as the tumor necrosis factor TNFR receptor and an increase in the number of Annexin V-FITC+7aad-negative cells. Detected disorders of immune regulation are implemented against the background of polymorphism of candidate genes and reliably (p<0,05) are associated with variant alleles of neuroregulation genes ADRB2 (rs1042317) and ANKK1 (rs1800497) and alleles of wild gene type genes nr3C1 (rs6195) and CYP1A1 (rs1048943) and clinically signs of atherosclerosis in oil and gas production workers are complicated by arterial hypertension, as opposed to workers who do not have constant contact with man-made production factors.
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G.G. Gimranova, L.K. Karimova, T.M. Zotova, A.E. Bakirova, R.R. Yakhina, Occupational health risks of workers involved in oil refining, Occupational health and human ecology, № 11, pp.9-12, 2009 [in Russian]
Karamova L.M., Basharova G.R., Valeyeva E.T., Galimova R.R., Vlasova N.V., Gazizova N.R. Health status of healthy oil and petrochemical workers, Occupational health and human ecology, vol.4, pp. 270-275, 2015 [in Russian]
M.Yu. Kuzmina, M.V. Shubin, Professional risks health of workers of the oil refining industry, Bulletin of Kazan technological University, №19, pp. 287 – 290, 2011 [in Russian]
R.R. Zakharova , G.N. Kalimullina , V.S. Romanov Working conditions and health status of oil refining workers, Occupational health and human ecology, vol.4, pp. 120-122, 2015 [in Russian]
E.B. Iskakov Prevalence of risk factors for cardiovascular diseases, Medicine and ecology, vol.3, i.84, pp.17 – 24, 2017 [in Russian]
M. Raieian-Kopaei, M. Setorki, M. Doudi et al. Atherosclerosis: process, indicators, risk factors and new hopes, International Journal of Preventive Medicine, vol. 8, i.5, pp. 927-946, 2014.
D. Mozaffarian, Heart disease and stroke statistics - 2015 update. A report from the American heart association, Circulation, No 131. p.295, 2015
P. Duramad, N.T. Holland, Biomarkers of immunotoxicity for environmental and public health research, International Journal of Environmental Research and Public Health, vol. 8, i.5, pp. 1388–1401, 2011
O.V.Dolgikh, A.V.Krivtsov, K.G.Starkova, O.A.Boubnova, D.G. Dianova, N.A. Vdovina, V.M. Uhabov, Immune and genetic changes in workers exposed to industrial noise and dust, Occupational health and human ecology, vol.9, i.2, pp. 551-553, 2015 [in Russian]
M.H. Shogenova , R.A. Zhetisheva, A.M., Karpov , Y.V. Dotsenko, V.P. Masenko, V.G. Naumov, The role of oxidized low-density lipoproteins and antibodies against oxidized low-density lipoproteins in the immune and inflammatory process in atherosclerosis, Atherosclerosis and Dyslipidaemias, No2, pp.17 – 21, 2015. [In Russian];
C.M. Scull, I. Tabas, Mechanisms of ER stress-induced apoptosis in atherosclerosis, Arteriosclerosis, thrombosis, and vascular biology, vol. 31, i.12, pp. 2792-2797, 2011.
W. Gu, J.Liu, Z. Wang, Y. Liu, S. Wen. ADRB2 polymorphisms and dyslipidemia risk in Chinese hypertensive patients, Clinical and Experimental Hypertension, vol. 39, i. 2, pp. 139-144, 2017
D.-W. Wang, M. Liu, P. Wang, X. Zhan, Y.-Q. Liu, L.-S. Zhao. ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease, Genetics and molecular biology, vol. 38, i.4, pp. 433-443, 2015.
S. Manfredi, C. Federici, M.G. Andreassi et al., GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 621, i. 1-2, pp. 106-112, 2007
C.S. Martins, D. Elias, L. M. Colli et al., HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome, Diabetes and metabolism research and reviews. vol. 33, i. 3. pp. e2842, 2017.
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