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CONTENT OF EXOGENIC HALOGENORGANIC COMPOUNDS IN THE BLOOD OF CHILDREN AND AN IMBALANCE OF THE CYTOKINE PROFILE
Abstract
Drinking water contamination with technogenic haptens forms an imbalance in the adaptive capabilities of the immune system in children. The aim of this work is to study the features of laboratory markers of the cytokine profile in children, probabilistically associated with an increased content of chloroform in the blood. Materials and methods. The study involved 283 children living in conditions of chronic low-level oral exposure to hyperchlorination products of drinking water, the control for which was a contingent formed of 224 children who consume drinking water of adequate quality in terms of chloroform content. The work used chemical-analytical, enzyme-linked immunosorbent assay methods. Results.Children consuming hyperchlorinated drinking water, chloroform has been identified in the blood, which should normally not be detected. It was found that under conditions of blood contamination with chloroform, a Th2-shift of the cytokine profile occurs with a statistically significant increase in the concentration of anti-inflammatory cytokines IL4 and IL6 in the blood, the frequency of excess was 2.2 and 4.3 times, respectively, relative to the values obtained in children unexposed to organohalogen compounds (p ? 0.001-0.031). Based on the construction of mathematical models of logistic regression, statistically significant (p <0.001) probabilistic causal relationships were established between the concentration of chloroform in the blood and an increase in the expression of IL4 (b0 = -2.55; b1 = 33.29; R = 0,57; F = 319.65). Conclusions.The presented results show that in children exposed to technogenichaptens, there is a change in the serum cytokine profile, characterized by the formation of a Th2-dependent immune response associated with excessive content of chloroform. The clinical reflection of this scenario is the development of an overly aggressive immune response in the form of allergies and autoimmune conditions.
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