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SELECTION OF TYPE OF POLYSACCHARIDE CARRIER FOR ENCAPSULATION OF MEDICINES
Abstract
Currently, systems for encapsulating drugs are widely used to obtain drugs, since they provide both the preservation of the activity of the administered drug and the reduction of side effects from its administration on the gastrointestinal tract. Complexes of natural polysaccharides such as chitosan alginate and chitosan pectin are widely used as such carriers. These complexes have high biological resistance and biodegradability. In addition, they provide the release of the drug at neutral pH values, which corresponds to the conditions of the human small intestine. At pH 2.0 (which corresponds to the acidity of the stomach), the release of the drug practically does not occur. The aim of this paper is to compare the effectiveness of the use of pectin-chitosan and alginate-chitosan complexes to obtain encapsulated forms of doxorubicin and oxytetracycline. Reagent concentrations were selected to provide microcapsules with a size of 600-800 nm, which is optimal for oral administration. The capacities of polysaccharide microcapsules for doxorubicin and oxytetracycline were determined. It was shown that the chitosan-pectin complex has a greater capacity for doxorubicin, and the chitosan-alginate complex has a greater capacity for oxytetracycline. The parallel and sequential release profile of drugs from microcapsules was studied. Microencapsulation has been shown to reduce the negative effect of doxorubicin on the activity of digestive enzymes, and oxytetracycline on the microflora of the gastrointestinal tract.
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The aim of this work was to compare the effectiveness of the use of pectin-chitosan and alginate-chitosan complexes to obtain encapsulated forms of doxorubicin and oxytetracycline. Doxorubicin is one of the main drugs used in chemotherapy. It has an extremely adverse effect on the stomach, causing the formation of stomach ulcers. Oxytetracycline is effective in the treatment of infectious diseases of the respiratory tract and the genitourinary system. However, with prolonged use, it disrupts the digestive system.
Reagent concentrations were selected to provide microcapsules with a size of 600-800 nm, which is optimal for oral administration. The capacities of polysaccharide microcapsules for doxorubicin and oxytetracycline were determined. It was shown that the chitosan-pectin complex has a greater capacity for doxorubicin, and the chitosan-alginate complex has a greater capacity for oxytetracycline. The parallel and sequential release profile of drugs from microcapsules was studied. Microencapsulation has been shown to reduce the negative effect of doxorubicin on the activity of digestive enzymes, and oxytetracycline on the microflora of the gastrointestinal tract.
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