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JUSTIFICATION OF THE ACCEPTABLE DAILY INTAKE OF PHTHALATES CONSUMED WITH MILK AS ENVIRONMENTAL HAZARD INDEX
Abstract
Phthalates and phthalic acid esters are actively used in the production of PVC-materials in order to make them resistant and flexible. They might migrate from the materials to the environment both under exposure to external physical factors, and without them. Phthalates impact negatively on the human organs and systems like the hormonal system, liver, kidneys. In addition, they have a systemic effect. The analysis of phthalates migration from polymer packaging into food is of the greatest interest for the research. Products remain the main source of several phthalates in the human body. Milk, which is one of the most frequently consumed food products by the population, draws special attention to the intake of phthalates in the human body. In the Custom Union countries, the phthalates migration is regulated without considering the eventual health risk. In this regard, it is advisable to develop hygienic standards taking into account the criteria of risk to public health. The development of acceptable daily intake (ADI) is one of the stages when working out the standards. The acceptable daily intake to phthalates entering with milk as per the health risk criteria was specified according to the methodology of the Eurasian Economic Union and included the following steps: analysis of relevant information for the hygienic assessment of the phthalates impact; the choosing of starting points and modifying factors for the ADI calculation; establishing the permissible daily exposure to phthalates; assessment of milk consumption (in total, the survey involved 30 children aged 7-17 years as the most sensitive group of consumers included in further research). As a result, the maximum acceptable level can be calculated using the ADI, which ensures the absence of harmful phthalates effects at the level of 0.001174 mg/kg per day.
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