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DEVELOPMENT OF SYSTEMS FOR TARGETED DELIVERY OF INTERFERON ON THE BASIS OF CHITOSAN-ALGINATE NANOPARTICLES
Abstract
Diabetes type I is one of the most important medical and social problem of health in all countries of the world. Treatment of diabetes type I diabetes is based on insulin therapy. Introduction ?-2? interferon in addition to insulin therapy for patients with diabetes type I at the beginning of the disease can slow the progression of the disease and even achieve remission. Therefore, the purpose of this work was to develop a method of producing nanoparticles loaded with interferon for oral delivery systems of drugs. The optimum conditions for obtaining the biodegradable nanoparticles loaded with ?-2- interferon with a size of 600-800 nm on the basis of the natural polymers alginate and chitosan wich provides pH-dependent release of immobilized protein were selected. It was shown that the nanoparticles release the encapsulated ?-2?-interferon in an acidic environment of the stomach within 60 minutes no more than 15%. The main quality (78%) of the protein is released into the small intestine. It was shown by ELISA that immobilized in chitosan-alginate nanoparticles ?-2? interferon retains its activity not less than 85%.
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