SWS Academic Research eLibraryEarth & Planetary Sciences

Scholarly record

THE INFLUENCE OF COMPLEXATION WITH HYDROXYPROPYL-?-CYCLODEXTRIN AND SURFACTANTS ON THE DISSOLUTION PROFILE OF AMIODARONE HYDROCHLORIDE

Andreea Creteanu, Lacramioara Ochiuz, Madalina Vieriu, Cornelia Vasile, Gladiola Tantaru

First published: 2017-06-20https://doi.org/10.5593/sgem2017/61/s24.049View metrics

Abstract

The objective of the study was to increase the solubility of amiodarone hydrochloride by complexation with hydroxypropyl-пїЅ-cyclodextrin. After complexation a cyclodextrin/amiodarone inclusion complex was formed. The use of media containing surfactants is a suitable solubilizing method and as a result, a non-ionic surfactant - Tween 80 and an anionic one - sodium lauryl sulfate have been used. The dissolution profile of amiodarone hydrochloride and that of the inclusion complex, regarding the release of the active substance, with or without surfactants was carried out in simulated physiological environment, at pH 1.2 (simulated gastric fluids) and pH 6.8 (simulated intestinal fluids). The dissolution test was carried out using two USP validated methods: paddle II apparatus dissolution test and Enhancer cell dissolution test.

Publication Impact Profile

PlumX
  • Captures
  • Mendeley - Readers: 3
PLUMX see details

Publication details

Title
THE INFLUENCE OF COMPLEXATION WITH HYDROXYPROPYL-?-CYCLODEXTRIN AND SURFACTANTS ON THE DISSOLUTION PROFILE OF AMIODARONE HYDROCHLORIDE
Authors
Andreea Creteanu, Lacramioara Ochiuz, Madalina Vieriu, Cornelia Vasile, Gladiola Tantaru
Proceedings
SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings; 17th International Multidisciplinary Scientific GeoConference SGEM2017, Nano, Bio and Green - Technologies for a Sustainable Future
Publisher
STEF92 Technology
Year
2017
Pages
375-382
SWS Citekey
Creteanu201724375382
ISSN
1314-2704
ISBN
978-619-7408-12-6
Language
en
Publication type
Conference Paper
Keywords
amiodarone hydrochloridesurfactantsdissolution test.
References0
0references registered for this publication

Structured references will appear here after the reference import pass. The count is preserved now so the scholarly record is not incomplete.

View or Download full articleAccess options
Full paper accessChoose SWS login, librarian support, or instant article download.

SWS access login

Login as SWS Scientific Committee

Authors and approved SWS contributors will read and export their own linked papers after identity matching by SWS profile, email and SGEM GlobalID.

For librarian assistance: [email protected]

Purchase Instant Access

48-hour online accessComing soon
Online-only accessComing soon
Download the full article in PDF formatEUR 35
  • Article can be downloaded after successful payment.
  • Article may be used according to SWS library access terms.
  • Article cannot be redistributed.
Get full paper

Back to publication list