Scholarly record
THE EFFECTS OF THE SOLUTION PARAMETERS ON ELECTROSPINNING OF POLY VINYL ALCOHOL
Abstract
Fabrication of nanofibers is a field of research attracting a lot of interest from technologici scientists because of its great applications in many fields. In order to design the polymer drug delivery system, we had to select a polymer that is biocompatible, biodegradable, non-toxic and approved for medical use. One of the polymers that fulfill those requirements is poly (vinyl alcohol) (PVA). There have been various reports on the fabrication of PVA nanofibers with solvents as water, or water with different salts, water with boric acid or dimethylformamide. However, all chemicals used above are not preferred options for the design of drug-containing nanofiber systems. Solvents chosen for use in our systems are non-toxic, volatile, inexpensive, and minimizes residue of chemicals during and after electrospinning. Therefore, acetic acid and ethanol are the two co-solvents which have been investigated in this study. We have investigated the PVA ratio, the effect of solvents including deionized water, acetic acid, ethanol and their mixture on the PVA nanofibers formation by electrospinning method. We have successfully fabricated PVA nanofibers with polymer content equal to 12%, CH3COOH 30%, the rest was deionized water. The sizes of these fibers were from 279 to 631 nm, the mean was 349 nm and the median was 343 nm. We found that an aqueous solution of acetic acid is very favorable for electrospun PVA fibers. Compared to the fabrication of nanofibers from aqueous PVA aqueous solution, the addition of acetic acid generally reduced the fiber diameter, and the fiber size distribution become more concentrated. However too high acid concentration inhibits fibers formation. Ethanol added to the solvent system was not favorable for the fabrication of nanofibers from PVA. Research on PVA nanofibers is the first step that provides data and basis for our future studies, that is to combine PVA with various biopolymers and then incorporate the drugs into the polymer matrix formed to serve the purpose of fabricating of drug nanofiber systems.
Publication Impact Profile
- Citations
- CrossRef - Citation Indexes: 2
- Scopus - Citation Indexes: 1
- Captures
- Mendeley - Readers: 5
Publication details
References15
Taylor, G. Disintegration of Water Drops in an Electric Field. Proc. R. Soc. Lond. A. Math. Phys. Sci. 1964, Vol. 280, pp. 383–397, DOI: 10.1098/rspa.1964.0151.
Snetkov, P.P., Uspenskaia, T.E., Uspenskaya, M.V., Rzametov, K.S., Effect of technological parameters on electrospinnability of water-organic solutions of hyaluronic acid, 19th International Multidisciplinary Scientific Geoconference, SGEM 2019; Albena; Bulgaria; 30 June 2019 through 6 July 2019, Volume 19, Issue 6.1, 2019, pp. 193-182. DOI: 10.5593/sgem2019/6.1/S24.023.
Snetkov, P., Morozkina, S., Olekhnovich, R., Nhung Vu, T.H., Tyanutova, M., Uspenskaya, M. Curcumin/usnic acid-loaded electrospun nanofibers based on hyaluronic acid. Materials, Vol. 13, Issue 16, Article number 3476, DOI: 10.3390/MA13163476
Glazacheva, E.N., Uspenskii, A.B., Voronova, A.A., Uspenskaya, M., Snetkov, P.P., Functional medical materials based on biopolymers: Preparation and investigation of structure and physico-chemical properties, 18th International Multidisciplinary Scientific Geoconference, SGEM 2018; Albena; Bulgaria; 2 July 2018 through 8 July 2018, Volume 18, Issue 6.1, 2018, Pages 219-226. DOI: 10.5593/sgem2018/6.1/S24.030.
Teodorescu, M.; Bercea, M.; Morariu, S. Biomaterials of PVA and PVP in medical and pharmaceutical applications: Perspectives and challenges. Biotechnol. Adv. 2019, Vol. 37, Issue 1, pp. 109–131. DOI: 10.1016/j.biotechadv.2018.11.008.
Marin, E.; Rojas, J.; Ciro, Y. A review of polyvinyl alcohol derivatives: Promising materials for pharmaceutical and biomedical applications. African J. Pharm. Pharmacol. 2014, Vol. 8, pp. 674–684. DOI: 10.5897/AJPP2013.3906.
Muppalaneni, S.; Omidian, H. Polyvinyl Alcohol in Medicine and Pharmacy: A Perspective. J. Dev. Drugs 2013, Vol. 2, Issue 3, 1000112,. DOI: 10.4172/2329-6631.1000112.
Gajra, B.; Pandya, S.S.; Vidyasagar, G.; Rabari, H.; Dedania, R.R.; Rao, S. Poly vinyl alcohol hydrogel and its pharmaceutical and biomedical applications: A review. Int. J. Pharm. Res. 2012, Vol. 4, Issue 2, pp. 20–26.
Raphael M. Ottenbrite, Kinam Park, Teruo Okano. Biomedical Applications of Hydrogels Handbook; Springer: New York, 2010, p. 432.
Q. Li, Z. Jia, Y. Yang, L. Wang and Z. Guan, Preparation and Properties of Poly (vinyl alcohol) Nanofibers by Electrospinning, 2007 IEEE International Conference on Solid Dielectrics, Winchester, 2007, pp. 215-218. DOI: 10.1109/ICSD.2007.4290790.
Shi, Y.; Zhao, Y.; Li, X.; Yan, D.; Cao, D.; Fu, Z. Enhancement of the mechanical properties and thermostability of poly(vinyl alcohol) nanofibers by the incorporation of sodium chloride. J. Appl. Polym. Sci. 2018, Vol. 135, Issue 13, 45981. DOI: 10.1002/app.45981.
Rwei, S.; Huang, C.-W.; Hung, C.-C. Electrospinning PVA Solution-Rheology and Morphology Analyses. Fibers Polym. 2012, Vol. 13, Issue 1, pp. 44-50. DOI: 10.1007/s12221-012-0044-9.
Itoh, H.; Li, Y.; Chan, K.H.K.; Kotaki, M. Morphology and mechanical properties of PVA nanofibers spun by free surface electrospinning. Polym. Bull. 2016, Vol. 73, Issue 10, pp. 2761–2777. DOI: 10.1007/s00289-016-1620-8.
Medina, E.F.; Arjona, S.D.; Corrales, F.Z.; Borras, V.A. Morphological and mechanical response characterization of nanofiber aggregates of pva produced by electrospinning sol-gel process. Dyna 2013, Vol. 80, pp. 109–114.
Alwan, T.J.; Toma, Z.A.; Kudhier, M.A.; Ziadan, K.M. Preparation and Characterization of the PVA Nanofibers produced by Electrospinning. Madridge J Nanotechnol Nanosci 2016, Vol. 1, 1–3, DOI: 10.18689/mjnn-1000101.
Citing literature
Number of times cited according to Crossref: 2
View or Download full articleAccess options
SWS access login
Login as SWS Scientific CommitteeLogin as SWS Scientific PartnerLogin as SWS AuthorAuthors and approved SWS contributors will read and export their own linked papers after identity matching by SWS profile, email and SGEM GlobalID.
For librarian assistance: [email protected]
Purchase Instant Access
- Article can be downloaded after successful payment.
- Article may be used according to SWS library access terms.
- Article cannot be redistributed.