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FUNCTIONAL MEDICAL MATERIALS BASED ON BIOPOLYMERS: PREPARATION AND INVESTIGATION OF STRUCTURE AND PHYSICO-CHEMICAL PROPERTIES
Abstract
The combination of polyester polyhydroxybutyrate with polysaccharide chitosan allow to increase the terms of biodegradation and improve the mechanical characteristics of biomaterial. The investigation of compatibility of the polymers in the composition demonstrates that the content of polyhydroxybutyrate in the composition should not exceed 60% weight. Also the increase in content polyhydroxybutyrate reduces the mechanical properties of the composition. To provide the porosity of biomaterial crosslinking agent can be used. Calcium chloride is effective for cross-linking the structure of chitosan and polyhydroxybutyrate, also this material is non-toxic. In this paper, the study of porous biopolymer films based on chitosan and polyhydroxybutyrate, using calcium chloride as a cross-linking agent, was carried out. The presumable results of this study are the formation of intermolecular hydrogen bonds between the functional groups of chitosan and polyhydroxybutyrate and possibility of application of calcium chloride as suitable non-toxic material for cross-linking biopolymers, allowing them to make their structure stronger and improve their mechanical properties.
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