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MICROSPHERICAL PARTICLES OF COMPOSITE DRUG BASED ON SODIUM CASEINATE FOR INHALATION ADMINISTRATION
Abstract
Inhalation delivery is a promising route of drug administration, including systemic action. It should be considered that the particles of drug aerosol should have a diameter in the range of 1 to 3 ?m. Microspherical particles based on protein molecules can provide increased bioavailability of drugs with poor water solubility. In the present work, microspherical particles of sodium caseinate with a model hydrophobic drug ? phenacetin were obtained using spray drying method. Average aerodynamic diameter of resulting particles was 1,3 ?m. It was found that the use of sodium caseinate allows not only to increase the dissolution rate of phenacetin, but also to increase its content in water solution. The obtained results allow to design a strategy for the generating of inhalation delivery systems for drugs with poor water solubility based on the protein matrix.
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