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CHEMICAL CO-PRECIPITATION SYNTHESIS AND CHARACTERIZATION OF POLYETHYLENE GLYCOL COATED IRON OXIDE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

Jano Markhulia

First published: 2017-06-20https://doi.org/10.5593/sgem2017/61/s24.007View metrics

Abstract

Surface modified superparamagnetic iron oxide nanoparticles (SPIONs) are a kind of novel functional materials, which have been widely used in the various areas. The main requirements to magnetic nanoparticles for biomedical applications are the nontoxicity, biocompatibility and high-level accumulation in the target tissue or organ, chemical stability, simplicity and reproducibility of synthesis. The composition and characteristics of the SPION surface have a strong influence on their stability, distribution, and biocompatibility, with regard to cellular uptake and cytotoxicity. This study is focused on the development of the synthesis of aqueous suspensions of SPIONs stabilized with hydrophilic polymer - polyethylene glycol (PEG). Iron oxide nanoparticles were synthesized via a controlled co-precipitation technique in the vacuum environment. Crystalline structures and particle sizes obtained iron oxide nanoparticles were characterized using X-ray diffraction (XRD) and Transmission Electron Microscopy (TEM). Magnetic properties were studied using the Vibrating Sample Magnetometer (VSM). Also, investigated the influence of PEG-coated SPIONs on the viability of the bacterial colonies of the Staphylococcus epidermidis. The detected bactericidal effect was time and growth phase-dependent. The outcomes of this study will further lead to the possible application of SPIONs for human chronic wound healing.

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Publication details

Title
CHEMICAL CO-PRECIPITATION SYNTHESIS AND CHARACTERIZATION OF POLYETHYLENE GLYCOL COATED IRON OXIDE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
Authors
Jano Markhulia
Proceedings
SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings; 17th International Multidisciplinary Scientific GeoConference SGEM2017, Nano, Bio and Green - Technologies for a Sustainable Future
Publisher
STEF92 Technology
Year
2017
Pages
51-58
SWS Citekey
Markhulia2017245158
ISSN
1314-2704
ISBN
978-619-7408-12-6
Language
en
Publication type
Conference Paper
Keywords
Magnetic nanofluidsPEGMagnetic nanoparticlesbactericideStaphylococcus epidermidis
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