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FORMULATION AND CHARACTERIZATION OF NEW MODIFIED-RELEASE TOPICAL ANTINEOPLASTIC PRODUCTS

Lăcrămioara Ochiuz

First published: 2018-06-20https://doi.org/10.5593/sgem2018/6.1/s24.029View metrics

Abstract

Skin cancer is a disease with an increasing incidence due to its complex etiology and various forms of manifestation. The topical treatment can be a successful therapeutic approach in early diagnosed cutaneous neoplasm. The main drawback of the drugs currently in use is the low bioavailability caused by many pathophysiological and pharmaceutical factors. The aim of the present study was to develop new modifiedrelease topical products by encapsulating bexarotene into biocompatible silica matrices and by formulating these systems as semisolid excipients. Bexarotene is a third generation retinoid highly selective to the retinoid X receptor and it is topically administered in the therapeutic management of skin lesions caused by T-cell lymphoma.Two semisolid bases were selected and a physical, chemical, sensory and pharmacotechnical characterization of the preparation was performed. The in vitro availability and kinetic release profile of bexarotene in the formulated products was measured. The results obtained showed a prolonged release of bexarotene from the formulations studied over a period of time longer than 8 hours. These results may be used as a basis for further in vivo studies, which are required for the assessment of the therapeutic efficacy of new topical agents with antineoplastic activity.

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Publication details

Title
FORMULATION AND CHARACTERIZATION OF NEW MODIFIED-RELEASE TOPICAL ANTINEOPLASTIC PRODUCTS
Authors
Lăcrămioara Ochiuz
Proceedings
SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings; 18th International Multidisciplinary Scientific GeoConference SGEM2018, Nano, Bio and Green - Technologies for a Sustainable Future
Publisher
STEF92 Technology
Year
2018
Pages
213-218
SWS Citekey
Ochiuz201824213218
ISSN
1314-2704
ISBN
978-619-7408-50-8
Language
en
Publication type
Conference Paper
Keywords
silica matricesbiomaterialsbexaroteneanticancer products
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