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CYTOTOXIC EFFECT OF CHELIDONIUM MAJUS FREEZE DRYED EXTRACT: IN VITRO STUDY ON SKIN CANCER LINE
Abstract
The multiple therapeutic properties of Chelidonium majus are known and well documented in the bibliography, being used for a long time in Chinese homeopathic medicine [1]. At the level of the skin, in traditional folk medicine, C. majus is used to treat warts, condylomas, and papillae, which are due to human papillomavirus (HPV) infections [2, 3]. In this context, the aim of this study was to assess the potential antitumor effects of C. majus extracts on human melanoma cells - A375 - and to evaluate it in terms of cell viability and morphology changes. Thus, an extract of C. majus (C_ex) was obtained in order to assess its potential antitumor effects. This extract was then tested on human melanoma cells - A375 - and evaluated in terms of cell viability and morphology changes. The results of the study highlighted the potential cytotoxic effect of C_ex on melanoma cells. It was observed that cell viability decreased in a dose-dependent manner after 24 hours. Moreover, the morphological changes are consistent with those observed following a cell viability test, exhibiting the characteristic signs of cell death.
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