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SYNTHESIS AND CHARACTERIZATION OF AMINO ACID-BASED, ECO-FRIENDLY MATERIALS
Abstract
Environmental pollution from polymer waste is one of the severe ecological problems. As of today, each day, approximately eight million pieces of plastic waste reach the ocean, where they are transformed into microplastics (small particles). Organisms in the sea are eating microplastics. The harmful effects of garbage ultimately affect humans. Due to the magnitude of the problem, the demand for biodegradable, eco-friendly materials, which will decompose after the operational period and will not pollute the environment, has increased in recent years. The latter contribute significantly to the sustainable development of the economy, as they are characterized by a wide range of uses and zero or minimal environmental impact [1-2]. The presented research concerns the synthesis of rigid structure monomers and biodegradable polymers based on them. Monomers tosyl diamino-diesters (TDADE) were synthesized by thermal condensation of amino acids and cyclic diols in a refluxed organic solvent. For the synthesis of polymers, we used the interfacial polycondensation method - we synthesized pseudoproteins of poly(ester urea) class (PP-PEU) by polycondensation of TDADE monomers with triphosgene. The paper presents the synthesis of six new monomers - TDADE and the preparation of some rigid structured poly(ester urea) based on them. Polymers of this type are actively used mainly in the medical field, however, due to their mechanical characteristics, the application area is expected to be some engineering fields as well.
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Wang Q, Zhang F., What does the China's economic recovery after COVID-19 pandemic mean for the economic growth and energy consumption of other countries? J Clean Prod. 2021 May 1;295:126265. DOI: 10.1016/j.jclepro.2021.126265. Epub 2021 Feb 10. PMID: 33589853; PMCID: PMC7874931
Sharma VK, Jinadatha C, Lichtfouse E. Environmental chemistry is most relevant to study coronavirus pandemics. Environ Chem Lett. 2020;18(4):993-996. DOI: 10.1007/s10311-020-01017-6. Epub 2020 May 20. PMID: 32837480; PMCID: PMC7237241
Vroman I, Tighzert L. (2009), Biodegradable polymers. Materials (Basel); 2(2): 307-344. DOI: 10.3390/ma2020307
Luckachan GE, Pillai CK.(2011), Biodegradable polymers - a review on recent trends and emerging perspectives. J Polym Environ; 19(3): 637-676 DOI: 10.1007/s10924-011-0317-1
Katsarava R., Gomurashvili Z., (2011) Biodegradable Polymers Composed of Naturally Occurring ?-Amino Acids. Book chapter in: Handbook of Biodegradable Polymers - Isolation, Synthesis, Characterization and Applications, Lendlein, A. and Sisson, A., Eds., Wiley-VCH, Verlag GmbH & Co. KGaA. Ch. 5, 107-131 DOI: 10.1002/9783527635818.ch5
Yousefzade O., Katsarava R, Puiggali J., (2020) Biomimetic Hybrid Systems for Tissue Engineering. Biomimetics 5 49 DOI: 10.3390/biomimetics5040049
Zavradashvili N., Puiggali J., Katsarava R., (2020) Artificial polymers made of ?- amino acids � Poly(Amino Acid)s, Pseudo-Poly(Amino Acid)s, Poly(depsipeptide)s, and Pseudo-Proteins, Current Pharm.Design., 26 (5), 566-593 DOI: 10.2174/1381612826666200203122110
Kobauri S., Kantaria T., Kupatadze N., Kutsiava N., Tugushi D., Katsarava R., (2019) Pseudo-proteins: A new family of biodegradable polymers for sophisticated biomedical applications, Nano Technology & Nano Science Journal, 1, 37-42
Katsarava R., Tugushi D., Gomurashvili Z.D., (2014) Poly (ester urea) Polymers and Methods of Use. U.S. Patent No. 8,765,164
Stakleff K.S., Lin F., Smith Callahan L.A., Wade M.B., Esterle A., Miller J., Becker M.L., (2013) Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. Acta Biomater. 9, 5132-5142 DOI: 10.1016/j.actbio.2012.08.035
Policastro G.M., Lin F., Smith Callahan L.A., Esterle A., Stakleff K S., Becker M.L., (2015) OGP functionalized phenylalanine-based poly (ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells. Biomacromolecules. 16, 1358-1371 DOI: 10.1021/acs.biomac.5b00153
Policastro G., Lin F., Esterle A., Harris F., Graham M., Katsarava R., Stakleff K.S., Becker M.L., (2015) OGP Functionalized Phenylalanine-based Poly(ester urea) for Enhancing Osteoinductive Potential of human Mesenchymal Stem Cells. 249th ACS National Meeting & Exposition, March 22-26, Denver, CO, USA DOI: 10.1021/acs.biomac.5b00153
Gomurashvili Z., Kricheldorf H.R., Katsarava R., (2000) Amino acid based bioanalogous polymers. Synthesis and study of new regular poly(ester amides)s composed of hydrophobic ?-amino acids and dianhydrohexitoles. J.Macromol. Sci.- Pure and Appl. Chem. 37, 215-227 DOI: 10.1081/ma-100101089
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