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UV-VIS FE-TIO2 PHOTO CATALYSIS OF CYCLOPHOSPHAMIDE AND ITS DEGRADATION INTERMEDIATES
Abstract
Cyclophosphamide - N,N - bis (2 - chloroethyl) - 1,3,2 пїЅ oxazaphosphinan пїЅ 2 -amine 2-oxide is one of the widely used drugs in cancer treatment, which presents genotoxic, carcinogenic, mutagenic and teratogenic potential. Previously reported studies proved that long time exposure to cyclophosphamide and their metabolites leads to negative effects upon the environment and human health. Therefore, there is a need for more performant treatment processes for cyclophosphamide advanced degradation from which heterogeneous photo catalysis represents a viable option. Taking into account these facts, UV-VIS photo catalysis of cyclophosphamide was performed in the following working conditions: 5%wt. Fe doped TiO2 dose of 200 mg/L and irradiation time up to 240 minutes. Photocatalytic experiments were performed using an UV reactor equipped with a medium pressure mercury lamp. Cyclophosphamide degradation efficiencies and identification of degradation intermediates was done via liquid chromatography coupled with mass spectrometry (LC-MS/MS) technique. Six degradation intermediates were identified via LC-MS/MS technique. Photocatalytic experiments were performed also in the presence of 2-propanol and F- as radicalsпїЅ scavengers showing that cyclophosphamide degradation most likely occurs in the bulk solution even if reaction between cyclophosphamide and catalyst surface adsorbed hydroxyl radicals is also possible.
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