RESEARCH CONCERNING PHARMACOLOGICAL PROPERTIES OF SOME NEW XANTHINE COMPOUNDS

Watanabe S., Yamakami J., Tsuchiya M., Terajima T., Kizu J. and Hori S. Antiinflammatory effect of theophylline in rats and its involvement of the glucocorticoidglucocorticoid receptor system, ? Pharmacol. Sci., 106(4):566-570, 2008;

Pilitsis J.G. and Kimelberg H.K. Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes, Brain Res. 798(l-2):294-303,1998;

Jain N., Puranik M., Lodha R. and Kabra S.K. Long-term management of asthma. Indian J. Pediatr., 4:S3 \A 1 , 200 1 ;

Santos-Silva A.J., Cairräo E., Morgado M., Alvarez E., and Verde I. PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries, Eur. J. Pharmacol., 582(1-3): 102-1 09, 2008;

Banner K.H and Page C.P.Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma, Eur. Respir. J., 8(6):996-1000, 1995;

Dubey R.K., Mi Z., Gillespie D.G. and Jackson E.K. Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth, Hypertension, 28(5):765771,1996;

Kim S.A., Marshall M.A., Melman N., Kim H.S., Müller CE., Linden J. and Jacobson K.A. Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions, J. Med. Chem. 45(1 1):2131-2138, 2002;

Heinonen I., Nesterov S.V., Kemppainen J., Nuutila P., Knuuti J., Laitio R., Kjaer M, Boushel R. and Kalliokoski K.K. Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans, J. Appi. Physiol., 103(6):2042-2048, 2007;

Bishnoi M., Chopra K. and Kulkarni S.K. Theophylline, adenosine receptor antagonist prevents behavioral, biochemical and neurochemical changes associated with an animal model of tardive dyskinesia, Pharmacol. Rep. 59(2): 181-191, 2007;

Kalla R.V., Elzein E., Perry T., Li X., Palle V., Varkhedkar V., Gimbel ?., Maa T., Zeng D. and Zablocki J. Novel 1,3-disubstituted 8-(l -benzyl- lH-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists, J. Med. Chem., 49(12):3682-3692, 2006;

Sankar J., Lodha R. and Kabra S.K. Doxofylline: The next generation methylxanthine, Indian J. Pediatr., 75(3):25 1-254, 2008;

Watanabe S., Yamakami J., Tsuchiya M., Terajima T, Kizu J. and Hori S. Antiinflammatory effect of theophylline in rats and its involvement of the glucocorticoidglucocorticoid receptor system, ? Pharmacol. Sci. 106(4):566-570, 2008;

Checchini M., Magni M., Scaglione M., Franzini C, Vaccarella A. and Omboni E. Controlled clinical study of doxophylline versus aminophylline in the treatment of acute cardiorespiratory insufficiency syndromes, Minerva Cardioangiol., 45(4): 185-190, 1997;

Feoktistov I., Polosa R., Holgate S.T. and Biaggioni I. Adenosine A2B receptors: a novel therapeutic target in asthma?. Trends. Pharmacol. Sci., 19(4): 148-53, 1998;

Profire L., Pascu M.C., Lupascu D., Stan CD. and Zamosteanu N. New theophylline derivatives with potential antiinflammatory effects, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 2008 (CD 278);