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SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES
Abstract
Sulfonamides are appropriate ligands for the preparation of coordination compounds with biological activity, as they possess bactericidal, antiviral, antidiabetic, and diuretic properties and some sulfonamide compounds are under clinical evaluation for cancer treatment. Metal complexes provide highly versatile platforms for drug design. Considering the biological potential of the quinoline nucleus, but also of the sulfonamide scaffold (especially antimicrobial), as well as that of the quinoline- sulfonamide combination we have decided to combine the two pharmacophore fragments. And at last, the complexation with divalent metals - M2+ (M2+: Zn2+, Cu2+, Co2+ and Cd2+) will bring complementary biological activity given by the cation with the final goal of achieving improved biological activity and better pharmacokinetic properties. The synthesized molecules were characterized by HRMS and NMR spectroscopy. The compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising.v
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