DEVELOPMENT OF PROLONGED-RELEASE SYSTEMS WITH MAGNOLOL BASED ON SILICA SBA-15

Chen Y.-H., et all. Liu P. -L., Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, Eur. J. Integrat. Med., 2011, 3, e317.

Lee Y.-J., Lee Y.M., Lee C.-K., Jung J.K., Han S.B., Hong J.T., Therapeutic applications of compounds in Magnolia family, Pharmacol. & Therap., 2011, 130, 157.

Wang L., Waltenberger B., at.all, Atanasov A.G., Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR- ): a review, Biochem. Pharmacol., 2014, DOI: 10.1016/j.bcp.2014.07.018

Tsai, T.H., et.all., Chen, C.F., Pharmacokinetic and pharmacodynamic studies of magnolol after oral administration in rats, Pharm. Pharmacol. Comm. 1996. 2, 191.

Lu, J., Liong, M., Li, Z.X., Zink, J.J., Tamanoi, F., Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals, Small, 2010, 6, 1794.

Vallet-Regi, M., Balas, F., Arcos, D., Mesoporous Materials for Drug Delivery , Angew. Chem. Int. Ed., 2007, 46, pp.7548.

Rosenholm, J.M., Linden, M., Towards establishing structure –activity relationships for mesoporous silica in drug delivery applications, J. Control. Rel., 2008, 128, 157.

Ferrari M, Cancer nanotechnology: opportunities and challenges, Nat. Rev. Cancer, 2005, 5, pp. 161.

Zhao D., Huo Q., Feng J., Chemlka B.F., Stucky G.D., Nonionic Triblock and Star Diblock Copolymer and Oligomeric Surfactant Syntheses of Highly Ordered, Hydrothermally Stable, Mesoporous Silica Structures, J. Am. Chem. Soc., 1998, 120, pp. 6024 - 6036;

Zhao D., Feng J., Huo Q., Melosh N., Frederickson G.H., Chmelka B.F., Stucky G.D., Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores, Science, 1998, 279, pp. 548 - 552.

Ryoo R., Ko C.H., Kruk M., Antochshuk V., Jaroniec M., Block-Copolymer- Templated Ordered Me soporous Silica: Array of Uniform Mesopores or Mesopore−Micropore Network J. Phys. Chem. B: Chem., 2000, 104, pp. 11465 - 11471.

F. Rouquerol, J. Rouquerol, and K. Sing, Adsorption by powders and porous solids, Acad. Press, 1999. International Multidisciplinary Scientific GeoConfenferences SGEM 2015 www.sgem.org

Chen Y.-H., et all. Liu P. -L., Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, Eur. J. Integrat. Med., 2011, 3, e317.

Lee Y.-J., Lee Y.M., Lee C.-K., Jung J.K., Han S.B., Hong J.T., Therapeutic applications of compounds in Magnolia family, Pharmacol. & Therap., 2011, 130, 157.

Wang L., Waltenberger B., at.all, Atanasov A.G., Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR- ): a review, Biochem. Pharmacol., 2014, DOI: 10.1016/j.bcp.2014.07.018

Tsai, T.H., et.all., Chen, C.F., Pharmacokinetic and pharmacodynamic studies of magnolol after oral administration in rats, Pharm. Pharmacol. Comm. 1996. 2, 191.

Lu, J., Liong, M., Li, Z.X., Zink, J.J., Tamanoi, F., Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals, Small, 2010, 6, 1794.

Vallet-Regi, M., Balas, F., Arcos, D., Mesoporous Materials for Drug Delivery , Angew. Chem. Int. Ed., 2007, 46, pp.7548.

Rosenholm, J.M., Linden, M., Towards establishing structure –activity relationships for mesoporous silica in drug delivery applications, J. Control. Rel., 2008, 128, 157.

Ferrari M, Cancer nanotechnology: opportunities and challenges, Nat. Rev. Cancer, 2005, 5, pp. 161.

Zhao D., Huo Q., Feng J., Chemlka B.F., Stucky G.D., Nonionic Triblock and Star Diblock Copolymer and Oligomeric Surfactant Syntheses of Highly Ordered, Hydrothermally Stable, Mesoporous Silica Structures, J. Am. Chem. Soc., 1998, 120, pp. 6024 - 6036;

Zhao D., Feng J., Huo Q., Melosh N., Frederickson G.H., Chmelka B.F., Stucky G.D., Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores, Science, 1998, 279, pp. 548 - 552.

Ryoo R., Ko C.H., Kruk M., Antochshuk V., Jaroniec M., Block-Copolymer- Templated Ordered Me soporous Silica: Array of Uniform Mesopores or Mesopore−Micropore Network J. Phys. Chem. B: Chem., 2000, 104, pp. 11465 - 11471.

F. Rouquerol, J. Rouquerol, and K. Sing, Adsorption by powders and porous solids, Acad. Press, 1999. International Multidisciplinary Scientific GeoConfenferences SGEM 2015 www.sgem.org