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Organs-on-chip allow for establishment of physiologically relevant models of human tissues and organs, and specifically of blood-brain barrier (BBB) and neurovascular unit (NVU) in their normal or pathological state. BBB/NVU integrity and functions are compromised in course of different diseases or injuries, like traumatic brain injury, stroke, multiple sclerosis, arteriovenous malformations, vascular dementia, Alzheimer?s disease, atherosclerosis, brain cancer, inflammation, genetic disorders, and many more. In t...