Browse

Amiodarone (AMD) is an antiarrhythmic agent used for the treatment of ventricular arrhythmias, arterial fibrillation, and severe rhythm disorders. The main therapeutic disadvantage of AMD is its low oral bioavailability and low water solubility. The aim of the study was to obtain the hydroxylpropyl-?-cyclodextrin/AMD inclusion complex and to assess its degree of drug loading using a new HPLC method. The solubilizing effect of cyclodextrin on AMD was evaluated by the phase solubility method. The concentration of AM...

The goal of the present study is to evaluate the use of mesoporous silicate nanoparticles MCM-41 for the loading and release of the magnolol. MCM-41 has a hexagonal arrangement of mesopores, with diameters ranging from 2 to 10 nm. The homogeneity of the cylindrical pores, high surface area with uniform porosity, and good thermal stability, which make them an attractive molecular sieve for applications in sorption of large organic molecules, as well as host for quantum confinement of guest molecules. Also, the bioc...

The objective of the study was to increase the solubility of amiodarone hydrochloride by complexation with hydroxypropyl-пїЅ-cyclodextrin. After complexation a cyclodextrin/amiodarone inclusion complex was formed. The use of media containing surfactants is a suitable solubilizing method and as a result, a non-ionic surfactant - Tween 80 and an anionic one - sodium lauryl sulfate have been used. The dissolution profile of amiodarone hydrochloride and that of the inclusion complex, regarding the release of the activ...