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Alzheimer?s disease (AD) is associated with conformational changes of amyloid-? peptides, which result in peptide oligomerization and fibril formation and, finally, in the appearance of senile plaques and extensive neuronal loss. However, the factors regulating the process of plaque-associated beta-amyloid peptide (A?) aggregation are only partly understood. Therefore, several ?-amyloid peptide fragments have been synthesized by SPPS according to Boc/Bzl strategy. Binding of metal ions to ?-amyloid peptides was st...

Alzheimer?s disease (AD) is associated with conformational changes of amyloid-? peptides, which result in peptide oligomerization and fibril formation and, finally, in the appearance of senile plaques and extensive neuronal loss. However, the factors regulating the process of plaque-associated beta-amyloid peptide (A?) aggregation are only partly understood. Therefore, several ?-amyloid peptide fragments have been synthesized by SPPS according to Boc/Bzl strategy. Binding of metal ions to ?-amyloid peptides was st...

Heavy and radioactive metal poisoning has become a problem of current interest as a result of environmental pollution on a global scale. Studies to test the noxious effect of radioactive metal ions on wheat germination and seedling growth showed that germination rate, shoot length, and fresh weights varied as a function of their concentration in the treatment solutions. We report here the effect of some radioactive and non-radioactive (stable) elements on the wheat seeds and seedlings (Triticum aestivum L.) in the...