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ANTIPROLIFERATIVE EFFECT OF POLYVINYLPYRROLIDONE-IODINE COMPLEX ON RHABDOMYOSARCOMA CELLS BY INDUCING CELL CYCLE ARREST
(STEF92 Technology, 2020-09-20, Assima Abekova, Roza Kenzhebekova, Rinat Islamov, Armen Nersesyan, lexander Ilin)
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PVP-I (povidone-iodine) or Betadine, molecular iodine combined with poly-(1-vinyl-2-pyrrolidone), has been reported as antimicrobial agent. It is also as a promising chemopreventive agent against cancer. In this study the antiproliferative effect of PVP-I on rhabdomyosarcoma (RD) and other cancer cell lines (AGS, HeLa, HepG2, and MiaPaCa2) was examined. Cancer cells were treated with PVP-I and assessed for cell proliferation, metabolic activity, colony forming assay, apoptosis, and the fluorometric assay of the ce...
Advances in Biotechnology2020