Browse

SARS-CoV-2 researchers faced the problem of specificity for ACE-2 receptors. In mice and rats, ACE-2 has a low affinity for this virus. In contrast, the Syrian hamster (Mesocricetus auratus) when infected with SARS-CoV-2 show clinical signs of infection with this virus. Therefore, it is necessary to assess the severity of pathological lesions and immune response for relevance to preclinical new drugs against SARS-CoV-2. In this study, we studied blood counts, serum levels of Il-6, TNF-?, IFN-? and IFN-? and the hi...

PVP-I (povidone-iodine) or Betadine, molecular iodine combined with poly-(1-vinyl-2-pyrrolidone), has been reported as antimicrobial agent. It is also as a promising chemopreventive agent against cancer. In this study the antiproliferative effect of PVP-I on rhabdomyosarcoma (RD) and other cancer cell lines (AGS, HeLa, HepG2, and MiaPaCa2) was examined. Cancer cells were treated with PVP-I and assessed for cell proliferation, metabolic activity, colony forming assay, apoptosis, and the fluorometric assay of the ce...