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The creation of in vitro model of human BBB, completely identical to the real BBB, was necessary for the possibility of studying the transport and penetration of drugs and xenobiotics and is still very popular and urgent task. In order to reproduce the most close to the real in vitro model of BBB, a microfluidic platform is used, which allows more carefully reproduce the structure of BBB, as well as physiological tangential stress on the surface of endothelial cells (0.3 - 2 PA). An innovative development was a ne...

The blood-brain barrier (BBB) is a functional structure of the brain that regulates the penetration into the Central nervous system of many foreign, toxic substances and compounds that penetrate into the blood or formed in the body itself, including drugs that can harm the nerve cells of the brain and spinal cord. BBB is not an insurmountable barrier separating the Central nervous system from the General internal environment. Its impermeability depends on the concentration and amount of substances in the blood, as...